Asxl1 deficiency in embryonic fibroblasts leads to cellular senescence via impairment of the AKT-E2F pathway and Ezh2 inactivation.

Although ASXL1 mutations are frequently found in human diseases, including myeloid leukemia, the cell proliferation-associated function of ASXL1 is largely unknown. Here, we explored the molecular mechanism underlying the growth defect found in Asxl1-deficient mouse embryonic fibroblasts (MEFs). We found that Asxl1, through amino acids 371 to 655, interacts with the kinase domain of AKT1.

Factors Influencing on Sexual Assertiveness of College Students.

Purpose: The purpose of this study was to identify the factors influencing sexual assertiveness in dating college students.

Methods: With a cross-sectional survey design, 468 college students who have had dating experiences were recruited and answered questionnaires. Data were analyzed using t-test, ANOVA with Scheffe? test, Pearson's correlation coefficients, and multiple regression.