Publications by authors named "Seung-Sook Lee"

Article Synopsis
  • Online e-learning has gained popularity among pathologists since the late 1990s, offering convenience and affordability, especially highlighted during the COVID-19 pandemic.
  • A new web/mobile-based platform called "CytoAcademy" has been developed to enhance continued medical education in cytopathology, featuring resources like lectures, archived whole-slide images, and self-assessment tests.
  • The platform encourages interactivity among users, allowing them to identify learning gaps and adopt a proactive approach to mastering cytopathology.
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In the previous study (Im et al., 2022), we revealed microplastic (MP) was accumulated and cleared through the kidneys via PET imaging. Here, we aimed to identify the renal dysfunction due to polyethylene (PE) MP in the kidney tissue.

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Background: Radioimmunotherapy (RIT) is a rare treatment option for relapsed or refractory B-cell non-Hodgkin's lymphoma (NHL). We investigated the safety and efficacy of I-rituximab in patients with relapsed or refractory marginal zone lymphomas.

Methods: Patients with pathologically confirmed marginal zone lymphoma who relapsed or were resistant to prior therapy were enrolled.

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The cytological diagnosis of lymph node lesions is extremely challenging because of the diverse diseases that cause lymph node enlargement, including both benign and malignant or metastatic lymphoid lesions. Furthermore, the cytological findings of different lesions often resemble one another. A stepwise diagnostic approach is essential for a comprehensive diagnosis that combines: clinical findings, including age, sex, site, multiplicity, and ultrasonography findings; low-power reactive, metastatic, and lymphoma patterns; high-power population patterns, including two populations of continuous range, small monotonous pattern and large monotonous pattern; and disease-specific diagnostic clues including granulomas and lymphoglandular granules.

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Article Synopsis
  • - The study assessed the effectiveness of ImmunoGenius software in diagnosing hematolymphoid neoplasms using real-world data from 25 university hospitals in Korea from 2015 to 2016.
  • - A total of 3052 cases were analyzed, with ImmunoGenius achieving a precision hit rate of 84.5%, indicating its reliability compared to 95% for in-house data.
  • - While the software performed well for B-cell lymphomas and was generally accurate for T-cell lymphomas, inaccuracies were mostly due to atypical IHC profiles and overlapping characteristics of similar diseases, suggesting the need for integrating clinical insights in the diagnostic process.
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Aim: This study aimed to evaluate the safety and efficacy of I-rituximab in patients with relapsed or refractory follicular or mantle cell lymphoma.

Methods: Twenty-four patients with relapsed or refractory follicular or mantle cell lymphoma were administered unlabeled rituximab (70 mg) immediately before receiving a therapeutic dose of I-rituximab. Contrast-enhanced 18F-fluorodeoxyglucose positron emission tomography/computed tomography was used a month later to assess tumor response.

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Background: Fine needle aspiration cytology (FNAC) is a valuable tool for evaluating lymphadenopathy. The purpose of this study was to assess the reliability and effectiveness of FNAC in the diagnosis of lymphadenopathy.

Methods: Cytological characteristics were evaluated in 432 patients who underwent lymph node FNAC and follow-up biopsy at the Korea Cancer Center Hospital from January 2015 to December 2019.

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Genetic analysis has great potential as a tool to differentiate between different species and breeds of livestock. In this study, the optimal combinations of single nucleotide polymorphism (SNP) markers for discriminating the Yeonsan Ogye chicken () breed were identified using high-density 600K SNP array data. In 3,904 individuals from 198 chicken breeds, SNP markers specific to the target population were discovered through a case-control genome-wide association study (GWAS) and filtered out based on the linkage disequilibrium blocks.

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Although thyroid cancer is the most prevalent endocrine malignancy, overall patients with thyroid cancer have a good long-term survival. However, a small percentage of patients with progressive thyroid cancer have poor outcomes, and the genetic drivers playing a key role thyroid cancer progression are mostly unknown. Here, we investigated the role of the PINX1 in thyroid cancer progression.

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Radiation-induced colitis is a common clinical problem after radiation therapy and accidental radiation exposure. Myeloid-derived suppressor cells (MDSCs) have immunosuppressive functions that use a variety of mechanisms to alter both the innate and the adaptive immune systems. Here, we demonstrated that radiation exposure in mice promoted the expansion of splenic and intestinal MDSCs and caused intestinal inflammation due to the increased secretion of cytokines.

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The recessive white (locus ) phenotype observed in chickens is associated with three alleles (recessive white , albino , and red-eyed white ) and causative mutations in the tyrosinase () gene. The recessive white mutation () inhibits the transcription of exon 5 due to a retroviral sequence insertion in intron 4. In this study, we genotyped and sequenced the insertion in intron 4 to identify the mutation causing the unusual white plumage of Yeonsan Ogye chickens, which normally have black plumage.

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The primary cause of colorectal cancer (CRC) recurrence is increased distant metastasis after radiotherapy, so there is a need for targeted therapeutic approaches to reduce the metastatic-relapse risk. Dysregulation of the cell-surface glycoprotein podocalyxin-like protein (PODXL) plays an important role in promoting cancer-cell motility and is associated with poor prognoses for many malignancy types. We found that CRC cells exposed to radiation demonstrated increased TGFβ and PODXL expressions, resulting in increased migration and invasiveness due to increased extracellular matrix deposition.

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Colorectal cancer (CRC) is a recurring cancer that is often resistant to conventional therapies and therefore requires the development of molecular-based therapeutic approaches. Dopamine receptor D2 (DRD2) is associated with the growth of many types of tumors, but its oncogenic role in CRC is unclear. Here, we observed that elevated DRD2 expression was associated with a poor survival rate among patients with CRC.

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Article Synopsis
  • The Yeonsan Ogye (YO) chicken, a valuable natural heritage in Korea, features unique black characteristics and has been traditionally reared without systematic breeding methods.
  • This study aimed to assess the genetic diversity of 509 YO chickens using 12 specific microsatellite markers, revealing an average genetic variation and determining that the population can be divided into three distinct ancestry groups.
  • The findings suggest that developing a future breeding plan based on the genetic pedigree of selected animals with high diversity is essential for the conservation of the YO chicken population.
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This study aimed to investigate the predictive efficacy of positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) for the pathological response of advanced breast cancer to neoadjuvant chemotherapy (NAC). The breast PET/MRI image deep learning model was introduced and compared with the conventional methods. PET/CT and MRI parameters were evaluated before and after the first NAC cycle in patients with advanced breast cancer [n = 56; all women; median age, 49 (range 26-66) years].

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Radiation-induced multiorgan dysfunction is thought to result primarily from damage to the endothelial system, leading to a systemic inflammatory response that is mediated by the recruitment of leukocytes. The Eph-ephrin signaling pathway in the vascular system participates in various disease developmental processes, including cancer and inflammation. In this study, we demonstrate that radiation exposure increased intestinal inflammation via endothelial dysfunction, caused by the radiation-induced activation of EphA2, an Eph receptor tyrosine kinase, and its ligand ephrinA1.

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Background: It is difficult to distinguish parathyroid lesions (PLs) from thyroid lesions using fine needle aspiration cytology (FNAC) because of their proximity and their similar cytomorphological features.

Methods: FNAC smears of 46 patients with pathologically proven PLs that were histologically diagnosed as parathyroid adenoma (PA, = 35), parathyroid hyperplasia (PH, = 3), atypical parathyroid adenoma (APA, = 1), and parathyroid carcinoma (PC, = 7) were retrospectively reviewed and analyzed.

Results: Our initial cytological diagnoses indicated correct diagnoses in 31 of 46 PL patients (67%).

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Article Synopsis
  • Radioimmunotherapy (RIT) is a targeted therapy for non-Hodgkin lymphomas, but the role of the biomarker HIF-1α in this context is not well understood, despite the use of Atorvastatin (ATV) in combination with chemotherapy.
  • In experiments with Raji xenograft mouse models, it was found that ATV enhances the effectiveness of rituximab (I-RTX) by increasing its uptake and therapeutic impact, while also downregulating HIF-1α through the action of miR-346.
  • The results indicate that combining ATV with I-RTX can improve treatment outcomes for patients who are poorly responsive or exhibit radio-resistance in non-Hodgkin lymphoma
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Background: The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL). Based on the hypothesis that JAK2 is a therapeutic target, we performed a prospective pilot study using ruxolitinib.

Methods: Relapsed or refractory patients with HL or PMBCL were eligible for this study, and JAK2 amplification was assessed by fluorescence in situ hybridization.

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Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a provisional entity in the 2017 World Health Organization classifications. To further elucidate the clinicopathologic features of this new disease, we carried out a retrospective, multicenter analysis of 42 patients with MEITL. The median age of the patients was 59 years (range, 20-84 years), and 27 patients (64 %) were male.

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Purpose: The treatment outcome of brentuximab vedotin (BV) has not been related with CD30 expression in previous studies enrolling patients with a wide range of CD30 expression level. Thus, this study explored the efficacy of BV in high-CD30-expressing non-Hodgkin lymphoma (NHL) patients most likely to benefit.

Materials And Methods: This phase II study (Clinicaltrials.

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This trial was designed to investigate the efficacy and toxicity of bendamustine, carboplatin, and dexamethasone (BCD) for relapsed or refractory peripheral T-cell lymphomas (PTCLs), which would be expected to exhibit more promising clinical outcomes compared with bendamustine therapy alone. After treatments with BCD, eight patients exhibited a complete response (CR; 29%) and seven exhibited a partial response (PR; 25%). The overall response rate (ORR) was 54%.

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