Publications by authors named "Seung-Jun Kang"
Ketoconazole (KTZ) and itraconazole (ITZ) are antifungal agents that have a broad spectrum of activity against fungal pathogens. However, the therapeutic indications of many antifungal drugs, including those of the azole group, are restricted due to possible hepatotoxicity. We performed toxicogenomic analyses using and models to investigate the molecular mechanisms underlying the hepatotoxicity of two azole antifungal drugs.
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- Ethane dimethanesulfonate (EDS) is a harmful agent that specifically targets and destroys Leydig cells, which are important for testosterone production.
- In a study of TM3 Leydig cells treated with EDS, researchers found significant changes in gene expression, with 677 genes upregulated and 6756 downregulated after 3 and 24 hours, respectively.
- The analysis revealed that oxidative stress plays a crucial role in the cell death of TM3 cells affected by EDS, highlighting important pathways related to toxic effects, steroid production, and cell apoptosis.
miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenol.
Reprod Biol Endocrinol
September 2011
Background: It is known that some environmental chemicals affect the human endocrine system. The harmful effects of endocrine disrupting chemical (EDC) nonylphenol (NP) have been studied since the 1980s. It is known that NP adversely affects physiological functions by mimicking the natural hormone 17 beta-estradiol.
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