DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment.

Purpose: Developmentally regulated GTP-binding protein 2 (DRG2) regulates microtubule dynamics and G2/M arrest during docetaxel treatment. Poly ADP-ribose polymerase (PARP) acts as an important repair system for DNA damage caused by docetaxel treatment. This study investigated whether DRG2 expression affects response to PARP inhibitors (olaparib) using prostate cancer cell lines PC3, DU145, LNCaP-FGC, and LNCaP-LN3.

Comparison of anxiety and depression status between office and manufacturing job employees in a large manufacturing company: a cross sectional study.

Background: The aim of this study was to investigate whether type of work is associated with anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). Additionally, we investigated the impact of number of working hours on anxiety and depression.

Methods: A total of 1774 workers participated and completed the HADS to determine their levels of anxiety and depression.

Serial Ultrasound Findings After Laser Ablation for Benign Breast Lesions on Long-Term Follow-Up: Implications for Evaluation of Procedural Success.

Objective: The purpose if this study was to describe the follow-up ultrasound (US) findings of percutaneous US-guided laser ablation for small benign breast lesions, and to define the procedural success.

Background Data: There are limited reports on follow-up imaging after laser ablation, because the ablated tumors were generally resected by surgery.

Materials And Methods: US-guided laser ablation was performed on 19 benign breast lesions in 10 patients.