Publications by authors named "Seung-Hwan Oh"

Objective: The JR blood group system, officially designated ISBT JR 032, consists of a single antigen called Jr. This is a high frequency antigen in most populations. The Jr(a-) phenotype is more prevalent in Japanese and Asian populations.

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  • Northern temperate coniferous forests are important because they connect different types of forests, but they are facing problems from things like climate change and human activities.
  • Recent research focuses on how severe drought affects tree growth in these forests, studying specific species like Abies nephrolepis and Picea jezoensis.
  • Some trees recover well from drought, while others resist it better; however, the growth before a drought plays a big role in how they react, and new disturbances may happen because of climate change.
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Most triblock copolymer-based physical hydrogels form three-dimensional networks through micellar packing, and formation of polymer loops represents a topological defect that diminishes hydrogel elasticity. This effect can be mitigated by maximizing the fraction of elastically effective bridges in the hydrogel network. Herein, we report hydrogels constructed by complexing oppositely charged multiblock copolymers designed with a sequence pattern that maximizes the entropic and enthalpic penalty of micellization.

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Background: Identifying the underlying etiology of developmental delay/intellectual disability (DD/ID) is challenging but important. The genetic diagnosis of unexplained DD/ID helps in the treatment and prognosis of the disability in patients. In this study, we reported our experience of using whole exome sequencing (WES) of children with unexplained DD/ID.

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Coffin-Siris syndrome (CSS) is a rare congenital disorder characterized by coarse facial features, intellectual disability or developmental delay, and aplasia or hypoplasia of the tips of the fifth finger and/or toes. Mutations in genes affecting the switch/sucrose non-fermenting ATP-dependent chromatin remodeling complex are reported to cause CSS. Here, we describe three CSS patients.

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The electrode buffer layer is crucial for high-performance and stable OSCs, optimizing charge transport and energy level alignment at the interface between the polymer active layer and electrode. Recently, SnO has emerged as a promising material for the cathode buffer layer due to its desirable properties, such as high electron mobility, transparency, and stability. Typically, SnO nanoparticle layers require a postannealing treatment above 150°C in an air environment to remove the surfactant ligands and obtain high-quality thin films.

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Introduction: Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) disease entity primarily attributed to genetic or acquired abnormalities in the alternative complement pathway. TMA can manifest in kidney transplant (KT) recipients owing to various factors, resulting in diverse clinical presentations. Given its adverse effects on allograft function and patient prognosis, genetic diagnostic approaches for aHUS are essential.

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  • The study evaluated the performance of a new tuberculosis interferon-gamma release assay (IGRA), AdvanSureI3 TB-IGRA, against the existing T-SPOT test.
  • A total of 125 blood samples from adult volunteers were analyzed, and results showed a high agreement of 90.8% between the two tests, with a substantial Cohen's kappa coefficient of 0.740.
  • The findings indicated that AdvanSureI3 TB-IGRA results are comparable to T-SPOT, with increasing interferon-gamma levels correlating to higher spot counts in T-SPOT.
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Introduction: Next-generation sequencing helps clinicians diagnose patients with suspected genetic disorders. The current study aimed to investigate the diagnostic yield and clinical utility of prospective whole-exome sequencing (WES) in rare diseases.

Methods: WES was performed in 92 patients who presented with clinical symptoms suggestive of genetic disorders.

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  • - The study focuses on the growth of (BiSb)S solid solution nanowires on fluorine-doped tin oxide glass using physical vapor transport, controlling the composition by varying the temperature of the SbS source.
  • - Defect-free nanowires with distinct crystal structures were successfully grown, achieving specific aspect ratios, which varied with changes in composition and temperature of the SbS source.
  • - A retrograde behavior was observed where, despite higher evaporation flux from the SbS source, the compositions decreased at certain temperatures due to a reaction between the gaseous Sb species and the BiS source, confirmed by various microscopy and diffraction techniques.
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This study investigated the antioxidant effects of β-cryptoxanthin (BCX), hesperetin (HES), and icariin (ICA), and their effects on maturation of porcine oocytes and subsequent embryonic development of somatic cell nuclear transfer (SCNT). Treatment with 1 μM BCX (BCX-1) increased the developmental rate of porcine oocytes more than treatment with 100 μM HES (HES-100) or 5 μM ICA (ICA-5). The glutathione level and mRNA expression of antioxidant genes (, , and were more increased in the BCX-1 group than in the HES-100 and ICA-5 groups, while the reactive oxygen species level was more decreased.

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Objective: MacConkey agar (MAC) is commonly used as a primary medium for conventional bacterial identification in clinical microbiology laboratories. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized microbial identification and is considered a reliable identification tool. While conventional identification methods rely on colony characteristics, MALDI-TOF MS requires a pure isolate on a solid medium.

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Objective: The present study investigated whether protodioscin (PD), a steroidal saponin mainly found in rhizome of Dioscorea species, alleviates oxidative stress-induced damage of porcine oocytes during in vitro maturation.

Methods: Oocytes were treated with different concentrations of PD (0, 1, 10, 100, and 200 μM) in the presence of 200 μM H2O2 during in vitro maturation. Following maturation, spindle morphology and mitogen-activated protein kinase activity was assessed along with reactive oxygen species level, GSH activity, and mRNA expression of endogenous antioxidant genes at the MII stage.

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The technology of successful cryopreservation is a very important factor in research and commercial applications. However, the survival and development of the vitrified-thawed (VT) oocytes are lower than those of non-vitrified-thawed (non-VT) oocytes. This study investigated the effect of the addition of hydroxypropyl cellulose (HPC) to a vitrification solution of bovine oocytes.

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Pontocerebellar hypoplasia is a heterogeneous group of rare genetic neurodevelopmental disorders marked by early degeneration of the cerebellum and brainstem. Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia (MICPCH; MIM#300749) is a disorder caused by pathogenic loss-of-function variants in gene plays a critical role in brain development by controlling neuronal development and synapse formation. This report describes a 6-month-old Korean female infant with global developmental delay, sensorineural hearing loss, axial hypotonia with hypertonia of extremities, progressive microcephaly, and pontocerebellar hypoplasia.

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  • Pseudohypoparathyroidism (PHP) is a rare disorder where the body resists parathyroid hormone, leading to high PTH levels and low calcium but can initially show no symptoms in infants.
  • A 1-month-old girl was evaluated for elevated TSH levels and later found to have skin nodules linked to PHP through a biopsy, highlighting the condition's characteristics.
  • Genetic testing confirmed a specific mutation in both the girl and her mother, leading to an early PHP Ia diagnosis despite normal calcium and phosphorus levels, stressing the importance of careful examinations in patients with hypothyroidism.
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  • This study compared the effectiveness of β-cryptoxanthin (BCX), hesperetin (HES), and icariin (ICA) antioxidants in the maturation of porcine oocytes.
  • The results revealed that BCX outperformed HES and ICA in reducing reactive oxygen species (ROS), improving glutathione levels, and enhancing antioxidant gene expression during in vitro maturation (IVM).
  • BCX also increased blastocyst formation rates and may serve as a promising candidate for improving assisted reproductive technologies by mitigating damage caused by oxidative stress in aging oocytes.
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This study investigated the antioxidant activities of Sasa quelpaertensis Nakai extract (SQE), p-coumaric acid (PCA) and myricetin (MY), and their effects on the in vitro maturation and developmental ability of porcine oocytes. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) showed that 1 mg of SQE contained 3.92 μg of PCA and 0.

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Background: Transfusion of ABO blood group-mismatched blood or administration to the wrong recipient may result in fatal adverse events. To prevent these types of errors, various strategies have been employed. Recently, we developed a novel sample collection workflow for the pre-transfusion crossmatching test and patient recognition.

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