Background: Air pollution is a global health concern, with fine particulate matter (PM) constituents posing potential risks to human health, including children's neurodevelopment. Here we investigated associations between exposure during pregnancy and infancy to specific traffic-related PM components with Autism Spectrum Disorder (ASD) diagnosis.
Methods: For exposure assessment, we estimated PM components related to traffic exposure (Barium [Ba] as a marker of brake dust and Zinc [Zn] as a tire wear marker, Black Carbon [BC]) and oxidative stress potential (OSP) markers (Hydroxyl Radical [OP] formation, Dithiothreitol activity [OP], reactive oxygen species [ROS]) modeled with land use regression with co-kriging based on an intensive air monitoring campaign.