Publications by authors named "Seung Pil Jung"
Article Synopsis
- Breast cancer (BC) exhibits complex genomic changes, but the impact of age and ethnicity on its molecular variations is still not well understood.
- This study analyzed 843 BC patients in the K-MASTER program, focusing on differences between age groups and comparing findings with larger genomic databases to uncover ethnic disparities.
- Key results included a higher frequency of specific mutations in older patients and significant differences in cancer subtypes across ethnic groups, leading to the development of a model to predict responses to platinum-based chemotherapy based on unique molecular signatures.
Background: Taxanes are effective chemotherapy drugs for breast cancer care, but adverse effects pose a significant challenge in cancer treatment. Taxane-induced fluid retention and lower-extremity edema are two of the important dose-limiting toxicity and result in decreased quality of life (QoL). However, there is no standard of care to alleviate the symptoms.
View Article and Find Full Text PDFBackground: Capsular contracture is one of the most common and severe complications after implant-based breast reconstruction. Recently, prepectoral implant-based breast reconstruction using acellular dermal matrix (ADM) has become an alternative to subpectoral implant-based reconstruction. However, risk factors for capsular contracture associated with recent prepectoral reconstruction trends are not well refined yet.
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- In breast surgeries, the nipple-areola complex can lead to contamination by normal bacteria, making it hard to keep the surgical area completely sterile.
- This study focused on the bacterial profile of nipple flora in breast cancer patients who had implant-based reconstructions, linking the presence of bacteria to postoperative complications like capsular contracture.
- Results showed that nearly 47% of patients had positive cultures for bacteria, with significant findings that certain bacteria, especially Staphylococcus epidermidis, were associated with postoperative infections, emphasizing the need for further research on preventive measures like antibiotic treatment.
Breast cancer is a heterogeneous disease, and computed tomography texture analysis (CTTA), which reflects the tumor heterogeneity, may predict the prognosis. We investigated the usefulness of CTTA for the prediction of disease-free survival (DFS) and prognostic factors in patients with invasive breast cancer. A total of 256 consecutive women who underwent preoperative chest CT and surgery in our institution were included.
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- The study investigates the effects of DIEP flap surgery on the thickness of the rectus abdominis muscle using ultrasound imaging to evaluate abdominal wall integrity.
- A total of 31 patients were analyzed, with measurements taken from both the operated side and the non-operated side, revealing no significant differences in muscle thickness.
- The findings suggest that DIEP flap surgery has minimal impact on the abdominal donor site, supporting its safety and effectiveness for breast reconstruction post-mastectomy.
Article Synopsis
- - The study evaluates the effectiveness of axillary ultrasound (AUS) in detecting lymph node metastasis in patients with clinically T1-2 N0 breast cancer who had negative AUS results prior to sentinel lymph node biopsy (SLNB).
- - Out of 948 patients analyzed, the false negative rate of AUS was roughly 20%, while the rates of high nodal burden (HNB) were quite low at around 1-2%.
- - The findings indicate that while MRI has limitations (low positive predictive value), it can effectively confirm negative AUS results with a high negative predictive value, suggesting that some cases of SLNB might be safely omitted.
Article Synopsis
- The study investigates the incidence and risk factors of treatment-related acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) in breast cancer survivors, revealing a growing concern as survival rates improve.
- Data from over 153,000 breast cancer patients in Korea shows that those treated with anthracycline-based chemotherapy had a significantly higher risk of developing AML and MDS compared to those who did not receive this treatment.
- The findings indicate that while the overall incidence of AML/MDS is low, the risks remain elevated for at least 10 years, highlighting the need for careful monitoring and consideration of long-term complications in breast cancer treatment.
Article Synopsis
- An immediate lymphatic reconstruction (ILR) combining axillary reverse lymphatic mapping and lymphovenous anastomosis is being studied as a new surgical technique aimed at preventing upper extremity lymphedema in breast cancer patients after mastectomy.
- A cohort study analyzed 213 patients, comparing 30 who underwent ILR with 183 who did not, to assess the effectiveness of this preventive treatment.
- Results showed a significantly lower incidence of lymphedema in the ILR group (3.8%) compared to the control group (7.7%), indicating that ILR may help reduce the risk, but more extensive research is needed for validation.
Purpose: Clinically, breast cancer can be divided into 4 subtypes based on the presence of hormone receptors, human epidermal growth factor receptor 2 (HER2), and Ki-67. Because the pattern and time of recurrence vary according to the subtype, we evaluated whether there was a difference in overall survival (OS) among the subtypes according to the time and type of recurrence.
Methods: A total of 2,730 patients who underwent breast cancer surgery were analyzed.
Article Synopsis
- - The study evaluates trends in treatment for high-risk hormone receptor-positive, HER-2-negative breast cancer patients in Korea from 2000 to 2018, particularly focusing on the shift from adjuvant chemotherapy (CTx) combined with hormonal treatment (HT) to HT alone.
- - An analysis of data from nearly 41,000 women revealed a significant increase in the use of HT only, from 21% in 2000 to 64.6% in 2018, while overall survival (OS) rates showed no significant difference between the two treatment approaches.
- - The findings suggest that for selected patients, including those with T2N1 disease, HT alone may be a sufficient and safe treatment option
Purpose: We provide evidence for the reclassification of the :c.5017_5019del variant by presenting the clinicopathological characteristics, clinical outcomes, and family history of breast or ovarian cancer in 17 patients with this variant.
Methods: This study included breast or ovarian cancer patients tested for genes between January 2008 and June 2020 at 10 medical centers in Korea.
Aims: Chemotherapy-induced cardiotoxicity (CIC) is a significant complication, meanwhile myocardial damage might differ depending on chemotherapy agents and their timing. The aim of this study was to evaluate serial changes of layer-specific myocardial function in patients with breast cancer and their differences by the development time of CIC and chemotherapy agent.
Methods And Results: A total of 105 consecutive patients with breast cancer (age: 52.
Purpose: Mutations in the PIK3CA gene occur frequently in breast cancer patients. Activating PIK3CA mutations confer resistance to human epidermal growth factor receptor 2 (HER2)-targeted treatments. In this study, we investigated whether PIK3CA mutations were correlated with treatment response or duration in patients with HER2-positive (HER2+) breast cancer.
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- * A study evaluated a health consultation program in Daegu, Korea, from March to June 2020, involving 20 doctors and 504 recovered patients who completed surveys about the program's effectiveness.
- * Results showed high satisfaction, with doctors rating the program's effectiveness at 4.00 and patients at 3.95, suggesting the program positively impacted their reintegration and offering insights for future improvements in similar initiatives.
Article Synopsis
- BRCA1 and BRCA2 are crucial genes for DNA repair, and testing for mutations can help in understanding specific cancer traits and treatment options, but it's often complex.
- In a study involving 321 patients, genetic testing identified 26 with harmful BRCA variants and noted common mutations in genes like TP53 and PIK3CA across samples.
- The analysis showed significant differences in tumor mutation burden between patients with wild-type BRCA genes and those with pathogenic variants, highlighting the value of using next-generation sequencing for cancer diagnostics.
Article Synopsis
- Scientists looked at two types of breast cancer, invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC), to see how they compare in terms of patient health and survival.
- They found that ILC patients tend to have more advanced cases and more positive hormone receptors, while IDC patients usually have more severe disease features, but survival rates for both types were similar overall.
- It was noted that the hormone receptor status, especially ER negative and PR negative, could affect survival outcomes, suggesting that doctors should pay extra attention to these factors when treating patients.
Article Synopsis
- Secondary nipple reconstruction often faces challenges due to flattening after the initial procedure, and the best methods for effective reconstruction remain unclear.
- A review of data from March 2012 to January 2019 indicated that out of 27 reconstructed nipples, those using purse-string sutures showed 53% acceptable projection, while star flaps had a 75% success rate in achieving similar results.
- The study concludes that using tailored approaches like purse-string sutures and star flaps based on tissue condition can lead to satisfactory outcomes, with 73% of patients expressing overall satisfaction.
Objectives: To investigate whether machine learning-based prediction models using 3-T multiparametric MRI (mpMRI) can predict Ki-67 and histologic grade in stage I-II luminal cancer.
Methods: Between 2013 and 2019, consecutive women with luminal cancers who underwent preoperative MRI with diffusion-weighted imaging (DWI) and surgery were included. For prediction models, morphology, kinetic features using computer-aided diagnosis (CAD), and apparent diffusion coefficient (ADC) at DWI were evaluated by two radiologists.
Background: Free abdominal tissue transfer is considered the gold standard for autologous breast reconstruction. However, many plastic surgeons are concerned about the theoretical risk of flap-related or donor-site complications associated with previous abdominal surgery. Also, studies have reported conflicting results in the literature due to difference in surgical strategies used in each study.
View Article and Find Full Text PDFPurpose: Women with large and/or ptotic breasts are generally not considered candidates for nipple-sparing mastectomy because of concerns regarding the high incidence of postoperative complications including ischemic complications. Therefore, we adopted a vertical skin resection technique for nipple-sparing mastectomy, and obtained satisfactory results following immediate autologous breast reconstruction. In this study, we aimed to describe our operative technique and review its outcomes.
View Article and Find Full Text PDFPurpose: Endoscopic breast surgery for patients with breast cancer was introduced for its superior cosmetic outcomes; it was initially studied in the field of breast-conserving surgery and, more recently, in robotic-assisted nipple-sparing mastectomy (NSM). The main purpose of this study was to investigate the feasibility and safety of endoscopic NSM (E-NSM) in patients with breast cancer by comparing E-NSM and conventional NSM (C-NSM).
Methods: Between May 2017 and October 2020, we retrieved the records of 45 patients who underwent NSM with permanent silicone implants and divided them into the E-NSM group (20 patients) and the C-NSM group (25 patients), depending on the use of the endoscopic device.
Background: Fat grafting is now a common procedure for breast reconstruction. Many clinical studies have reported its aesthetic efficacy and oncological safety, but some experimental studies raise about the recurrence risk because of its regenerating property. This study aims to investigate the possibility of cancer recurrence associated with fat grafting.
View Article and Find Full Text PDFCorrection of malrotation in two-stage breast reconstruction: outcomes and risk-factor analysis.
J Plast Surg Hand Surg
February 2021
Article Synopsis
- The use of anatomical implants in breast reconstruction has caused concerns among surgeons, particularly regarding the issue of malrotation, which lacks sufficient literature and standard corrective approaches.
- A study analyzed 132 implants in 118 patients, finding that 12.9% suffered from malrotation, with significant risk factors identified as tissue expander malrotation and capsular contracture.
- It is recommended that patients with multiple risk factors switch to round implants for correction, and extra caution is necessary even with round implants due to the possibility of recurring malrotation.