SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma.

Background & Aims: SIRT1 is a class III histone deacetylase that plays diverse roles in various cancers. However, the clinical significance of SIRT1 in hepatocellular carcinoma (HCC) remains unknown.

Methods: We analysed p53 mutations and the activation of SIRT1 in 252 hepatitis B virus-positive HCC cases.

Conductive rubber electrode for wearable health monitoring.

For the continuous health monitoring, physiological signal must be able to measure for a long time in daily life. Therefore, health monitoring device was made as small as possible, and sensors must have a small effect by motion artifact. To reduce impedance between the user skin and the electrode, a conductive gel was applied to the metallic electrode, thereby facilitating converting ion current flowing in a living body into an electric current.