Cereblon contributes to cardiac dysfunction by degrading Cav1.2α.

Aims: Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that was reported to target ion channel proteins. L-type voltage-dependent Ca2+ channel (LTCC) density and dysfunction is a critical player in heart failure with reduced ejection fraction (HFrEF). However, the underlying cellular mechanisms by which CRBN regulates LTCC subtype Cav1.

Development of Thin-Film Composite Membranes from Aromatic Cardo-Type Co-Polyimide for Mixed and Sour Gas Separations from Natural Gas.

The consumption of natural gas (NG) is rapidly increasing worldwide as it is becoming the second largest fuel source after coal. However, many of the world gas reserves contain high levels of subquality NG including the presence of carbon dioxide (CO), hydrogen sulfide (HS), nitrogen (N), benzene/toluene/xylene (BTX) etc., in varying amounts (up to 50% v/v in some reserves), which constitute several problems.

Protective effect of L. seed on oxidative stress and cognitive impairment induced by chronic alcohol consumption in mice.

Chronic alcohol consumption induces damage to the brain that can cause various forms of dementia. An abundance of acetaldehyde is produced by excessive alcohol consumption and accumulates in the body to induce oxidative stress, apoptosis, and inflammation in neuronal cells, which results in learning and cognitive decline. In the present study, C57BL/N mice were orally administered alcohol (16%) and L.