Publications by authors named "Seung Gwa Park"
Article Synopsis
- Engineering tissue implants using human induced pluripotent stem cells (hiPSCs) shows potential for repairing large tissue losses but faces challenges in survival and integration.* -
- The study introduces scalable vessel-integrated muscle-like lattices (VMLs) that feature dense hiPSC-derived myofibers and vessel-like microchannels, enhancing myofiber maturation and host integration.* -
- This advanced bioprinting technology allows for the creation of larger, prevascularized muscle tissues, which successfully restore muscle function and promote healing in volumetric muscle loss injury models.*
The assay for transposase-accessible chromatin with sequencing (ATAC-seq) is the most widely used method for measuring chromatin accessibility. Researchers have included multi-sample replication in ATAC-seq experimental designs. In epigenomic analysis, researchers should measure subtle changes in the peak by considering the read depth of individual samples.
View Article and Find Full Text PDFIn the nucleus, distinct, discrete spots or regions called "foci" have been identified, each harboring a specific molecular function. Accurate and efficient quantification of these foci is essential for understanding cellular dynamics and signaling pathways. In this study, we present an innovative automated image analysis method designed to precisely quantify subcellular foci within the cell nucleus.
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- - PADI2 is an enzyme that converts peptidyl-arginine to peptidyl-citrulline, but its specific roles in bone formation are not well understood; this study aimed to clarify its functions using knockout mice.
- - The research found that a lack of PADI2 leads to bone mass loss and a cleidocranial dysplasia phenotype, which includes issues like delayed skull ossification and underdeveloped clavicles due to impaired osteoblast differentiation.
- - PADI2 stabilizes RUNX2, a key protein for bone formation, by preventing its degradation; the study identified crucial citrullination sites on RUNX2 that impact its stability, highlighting PADI2 as a potential
Although the normal physiological level of oxidative stress is beneficial for maintaining bone homeostasis, imbalance between reactive oxygen species (ROS) production and antioxidant defense can cause various bone diseases. The purpose of this study was to determine whether nicotinamide (NAM), an NAD precursor, can support the maintenance of bone homeostasis by regulating osteoblasts. Here, we found that NAM enhances osteoblast differentiation and mitochondrial metabolism.
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