Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine.

1. The renal excretion of organic cation drugs, including lamivudine, is mostly mediated by OCT2 in vitro. To date, three putatively relevant single nucleotide polymorphisms (SNPs), including c.

Frequency of CYP2C9 alleles in Koreans and their effects on losartan pharmacokinetics.

Aim: CYP2C9 enzyme metabolizes numerous clinically important drugs. The aim of this study is to investigate the frequencies of CYP2C9 genotypes and the effects of selected alleles on losartan pharmacokinetics in a large sample of the Korean population.

Methods: The CYP2C9 gene was genotyped in 1796 healthy Korean subjects.