Smad4 and p53 synergize in suppressing autochthonous intestinal cancer.

Background: Smad4 and p53 mutations are the most common mutations in human colorectal cancers (CRCs). We evaluated whether and how they are synergistic in intestinal carcinogenesis using novel autochthonous mouse models.

Method: To recapitulate human CRCs, we generated Villin-Cre;Smad4 ;Trp53 mice.