Biomarkers.

Background: Tauopathy is recognized not only as a pathological substrate but also exhibits a robust correlation with the clinical manifestations of dementia, leading to diverse neuropsychiatric manifestation. However, human brain functions as networks rather than modules. The conventional query of 'Where is the lesion (regionally)?' may inadequately capture the entirety of dementia manifestations.

Biomarkers.

Background: Tau-PET and plasma phosphorylated tau (p-tau) have emerged as pivotal biomarkers for Alzheimer's disease. Despite the practical advantages of using plasma p-tau, there is limited understanding regarding its relationship with the topographic distribution of tau-PET, particularly within the Southeast Asian population. This study aims to elucidate the correlation between plasma p-tau levels and the spatial patterns observed in tau-PET among Thai patients diagnosed with amnestic mild cognitive impairment (MCI) or mild dementia due to probable Alzheimer's disease (AD).

Alzheimer's Imaging Consortium.

Background: Tauopathy is recognized not only as a pathological substrate but also exhibits a robust correlation with the clinical manifestations of dementia, leading to diverse neuropsychiatric manifestation. However, human brain functions as networks rather than modules. The conventional query of 'Where is the lesion (regionally)?' may inadequately capture the entirety of dementia manifestations.

System dynamics modeling to understand mental model of public humiliation in medical education.

Background: Mistreatment in medical school is a wicked or complex problem demonstrating inter-relatedness and dynamicity of factors that affect students. Many studies have outlined the causes, perceptions, and negative consequences of mistreatment; however, a comprehensive mental model of public humiliation, the most common type of mistreatment, is still incomplete. This study aims to provide insight into the reasons why public humiliation in medical school continues to be a problem despite existing for decades, and to propose a shift in paradigm that potentially improve these incidents.