Synopsis of recent research by authors named "Setsuko Ameno"
- Setsuko Ameno's research primarily focuses on the neuropharmacological effects of acetaldehyde and its interaction with neurotransmitter systems, particularly dopamine and acetylcholine, in animal models, emphasizing the use of techniques like in vivo microdialysis and high-performance liquid chromatography.
- Significant findings include a dose-dependent effect of acetaldehyde on dopamine levels in the rat striatum, highlighting that high concentrations of acetaldehyde can notably decrease dopamine but do not significantly alter norepinephrine levels, suggesting a selective impact on neurotransmitter release.
- Ameno's work also investigates genetic risk factors associated with cardiac death, linking specific polymorphisms in genes related to nitric oxide synthesis and adrenergic receptors with the likelihood of coronary heart disease, thereby merging pharmacological research with genetic epidemiology.
