Publications by authors named "Setayesh Solouki"
Article Synopsis
- HTLV-1 is associated with serious diseases like adult T-cell leukemia/lymphoma and tropical spastic paraparesis, and understanding its prevalence in areas like Alborz province, Iran, is crucial.
- The study focused on the genetic analysis of the virus, particularly the highly conserved long terminal repeat (LTR) region and the Tax oncoprotein, to understand its phylogenetic relationships.
- Among about 15,000 blood donors, only 19 tested positive for HTLV-1, showing a 0.13% positivity rate, with the virus identified as subtype A; while mutations were present, they did not significantly impact the virus's functions or virulence.
Background: Adult T-cell Lymphoma/Leukemia (ATLL) is characterized by the malignant proliferation of T-cells in Human T-Lymphotropic Virus Type 1 and a high mortality rate. Considering the emerging roles of microRNAs (miRNAs) in various malignancies, the analysis of high-throughput miRNA data employing computational algorithms helps to identify potential biomarkers.
Methods: Weighted gene co-expression network analysis was utilized to analyze miRNA microarray data from ATLL and healthy uninfected samples.