Laser-assisted dacryocystorhinostomy of acquired dacryops in a dog.

Objective: To describe a novel minimally invasive surgical approach to treatment of a nasolacrimal duct cyst in a dog and outcome.

Animal Studied: A 10-year-old, male entire, Springer Spaniel with a chronic right-sided maxillary swelling and associated right eye epiphora and sneezing.

Procedure: Computed tomography with dacryocystography confirmed a cystic structure and destruction of the right maxilla and zygomatic bone with invasion of the nasal cavity.

Submucosal resection via a transanal approach for treatment of epithelial rectal tumors - a multicenter study.

Objective: To report complications and long-term outcomes after submucosal resections of benign and malignant epithelial rectal masses.

Study Design: Retrospective multicentric study.

Sample Population: Medical records of 93 dogs at 7 referral hospitals.

The missing link in gravitational-wave astronomy: A summary of discoveries waiting in the decihertz range.

Since 2015 the gravitational-wave observations of LIGO and Virgo have transformed our understanding of compact-object binaries. In the years to come, ground-based gravitational-wave observatories such as LIGO, Virgo, and their successors will increase in sensitivity, discovering thousands of stellar-mass binaries. In the 2030s, the space-based will provide gravitational-wave observations of massive black holes binaries.

Detectable Environmental Effects in GW190521-like Black-Hole Binaries with LISA.

GW190521 is the compact binary with the largest masses observed to date, with at least one black hole in the pair-instability gap. This event has also been claimed to be associated with an optical flare observed by the Zwicky Transient Facility in an active galactic nucleus (AGN), possibly due to the postmerger motion of the merger remnant in the AGN gaseous disk. The Laser Interferometer Space Antenna (LISA) may detect up to ten such gas-rich black-hole binaries months to years before their detection by Laser Interferometer Gravitational Wave Observatory or Virgo-like interferometers, localizing them in the sky within ≈1°^{2}.

No tension between assembly models of super massive black hole binaries and pulsar observations.

Pulsar timing arrays are presently the only means to search for the gravitational wave stochastic background from super massive black hole binary populations, considered to be within the grasp of current or near-future observations. The stringent upper limit from the Parkes Pulsar Timing Array has been interpreted as excluding (>90% confidence) the current paradigm of binary assembly through galaxy mergers and hardening via stellar interaction, suggesting evolution is accelerated or stalled. Using Bayesian hierarchical modelling we consider implications of this upper limit for a range of astrophysical scenarios, without invoking stalling, nor more exotic physical processes.

Spectroscopy of Kerr Black Holes with Earth- and Space-Based Interferometers.

We estimate the potential of present and future interferometric gravitational-wave detectors to test the Kerr nature of black holes through "gravitational spectroscopy," i.e., the measurement of multiple quasinormal mode frequencies from the remnant of a black hole merger.

Prospects for Multiband Gravitational-Wave Astronomy after GW150914.

The black hole binary (BHB) coalescence rates inferred from the Advanced LIGO detection of GW150914 imply an unexpectedly loud gravitational-wave (GW) sky at millihertz frequencies accessible to the Evolved Laser Interferometer Space Antenna (eLISA), with several outstanding consequences. First, up to thousands of BHBs will be individually resolvable by eLISA; second, millions of nonresolvable BHBs will build a confusion noise detectable with a signal-to-noise ratio of a few to hundreds; third-and perhaps most importantly-up to hundreds of BHBs individually resolvable by eLISA will coalesce in the Advanced LIGO band within 10 y. eLISA observations will tell Advanced LIGO and all electromagnetic probes weeks in advance when and where these BHB coalescences will occur, with uncertainties of <10  s and <1  deg^{2}.

Detectability of Gravitational Waves from High-Redshift Binaries.

Recent nondetection of gravitational-wave backgrounds from pulsar timing arrays casts further uncertainty on the evolution of supermassive black hole binaries. We study the capabilities of current gravitational-wave observatories to detect individual binaries and demonstrate that, contrary to conventional wisdom, some are, in principle, detectable throughout the Universe. In particular, a binary with rest-frame mass ≳10^{10}M_{⊙} can be detected by current timing arrays at arbitrarily high redshifts.

Limits on Anisotropy in the Nanohertz Stochastic Gravitational Wave Background.

The paucity of observed supermassive black hole binaries (SMBHBs) may imply that the gravitational wave background (GWB) from this population is anisotropic, rendering existing analyses suboptimal. We present the first constraints on the angular distribution of a nanohertz stochastic GWB from circular, inspiral-driven SMBHBs using the 2015 European Pulsar Timing Array data. Our analysis of the GWB in the ~2-90 nHz band shows consistency with isotropy, with the strain amplitude in l>0 spherical harmonic multipoles ≲40% of the monopole value.

In vitro activity of amphotericin B cochleates against Leishmania chagasi.

Cochleate delivery vehicles are a novel lipid-based system with potential for delivery of amphotericin B (AmB). In this study, the efficacy of cochleates was evaluated by examining the in vitro activity of AmB cochleates (CAMB) against Leishmania chagasi in a macrophage model of infection. We demonstrate that CAMB is nontoxic to macrophages at concentrations as high as 2.

Strong lensing of gravitational waves as seen by LISA.

We discuss strong gravitational lensing of gravitational waves from the merging of massive black hole binaries in the context of the LISA mission. Detection of multiple events would provide invaluable information on competing theories of gravity, evolution and formation of structures and, possibly, constraints on H0 and other cosmological parameters. Most of the optical depth for lensing is provided by intervening massive galactic halos, for which wave optics effects are negligible.