Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis.

Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils.

Effectiveness of correction of bleomycin-induced lung injury by early and late administration of surfactant-BL.

Rats were exposed to inhalation of surfactant-BL starting from the first or eighth day after intratracheal administration of bleomycin. At the early stages, the preparation effectively attenuated damage to ultrastructural components of the lung tissue and reduced the severity and extent of subsequent pulmonary pathology.

Therapeutic efficiency of early and late administration of surfactant-BL during bleomycin-induced damage to rat lungs.

Surfactant-BL was administered to rats via the inhalation route from day 1 or day 8 after intratracheal injection of bleomycin. Bronchoalveolar lavage and morphological characteristics of the lungs were compared. Administration of surfactant-BL at the early terms efficiently reduced the severity of bleomycin-induced alveolitis and atelectases.

[An experimental study of the tumor affinity of gallium-67-labelled sphingomyelin liposomes].

The level of accumulation of sphingomyelin liposomes with 67-Ga-labelled aqueous phase in tumor tissue proved higher than that of the vesicles with labelled lipid phase. Presence of cholesterol in sphingomyelin liposome membranes failed to influence liposome accumulation in tumor tissue. Neutral sphingomyelin vesicles with 67-Ga-labelled aqueous phase offer promise in scintigraphic imaging of tumors.

[Distribution in mice of 125I-monoclonal antibodies to T-lymphocyte antigen Ly 2.1 under the influence of immunomodulators].

A study was made of the distribution of 125I (a chloramine method of labeling) monoclonal antibodies to the surface antigen Ly 2.1 of T-lymphocytes during action of immunomodulators (tactivin, hydrocortisone, tactivin administered after hydrocortisone) on ACR mice. These antibodies were shown to retain antigen binding capacity, permitting monitoring of the redistribution of the antigen in the body exposed to immunomodulators.

[An experimental study of tumor-tropic properties of radionuclide-labeled liposomes].

The paper is concerned with the results of experimental investigations to develop methods for obtaining 99mTc and 67Ga-labeled liposomes, possessing tumor-tropic properties. Sphingomyelin vesiculae, labeled with 67Ga with the help of bifunctional chelates, were shown to possess a high level of hyperfixation. A study of biodistribution of these liposomes in rats with Plis lymphosarcoma showed that the level of accumulation of 67Ga-liposomes was enough to obtain a clear scintigraphic tumor image.

[The distribution of 125I-monoclonal antibodies to Bence Jones proteins in the body of animals].

A study was made of the biodistribution of 125I-labeled (chloramine, lactoperoxidase and iodogen tracer methods) monoclonal antibodies to free lambda and kappa chains of human immunoglobulins (Bence Jones proteins) using experimental models: ACR mice with a depot of antigen in the muscular tissue. Labeled MAB were shown to preserve their immunological properties. The results of investigation into biodistribution helped to reveal selective accumulation of radioactivity in the antigen depot (Bence Jones protein).