The Use of Tissue Engineering to Fabricate Perfusable 3D Brain Microvessels .

Tissue engineering of the blood-brain barrier (BBB) has been rapidly expanding to address the challenges of mimicking the native structure and function of the BBB. Most of these models utilize 2D conventional microfluidic techniques. However, 3D microvascular models offer the potential to more closely recapitulate the cytoarchitecture and multicellular arrangement of microvasculature, and also can recreate branching and network topologies of the vascular bed.