Publications by authors named "Serrand C"

Article Synopsis
  • A multicenter study evaluated the impact of a restrictive fluid strategy versus a standard fluid strategy in ICU patients with septic shock, aiming to minimize fluid intake to avoid complications from positive fluid balance.
  • By analyzing 48 patients over 5 days, the restrictive group received significantly less fluid (89.7 ml/kg vs. 114.3 ml/kg), resulting in a smaller cumulative fluid balance.
  • However, after 28 days, both groups showed similar mortality and survival without life support, indicating no clear benefits of the restrictive strategy despite differences in fluid management during the initial week.
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The prognostic value of BRAF V600 mutation level on clinical outcomes in patients with BRAF V600-mutated metastatic melanoma treated with BRAF and MEK inhibitors remains uncertain. The association was retrospectively analysed between BRAF V600 mutation level (defined as the ratio of the quantification of the BRAF V600 allele to the percentage of tumoral cells in the sample analysed) and progression-free and overall survival (PFS and OS, respectively) and 3-month response rate in a cohort of 58 patients with metastatic melanoma who harboured BRAF V600E/K mutations and received dual targeted-therapy BRAF/MEK inhibitors. The BRAF mutation level cut-off determined by the area under the receiver operating characteristic curve after internal validation by bootstrap methods was 0.

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Objective: People with intellectual disabilities (ID) have difficulty in accessing oral or written health information presented in a conventional manner what compromises prevention. This study aims to develop accessible information on breast, cervical and colorectal cancer screening for people with ID.

Method: The instructional material has been developed collaboratively by a team involving representatives from different scientific disciplines (medical and psychoeducational) and people with ID.

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  • The study aimed to evaluate how well an AI system can detect bone fractures compared to radiologists, using CT scans as the ultimate benchmark.
  • It involved 94 adult patients and found that the AI had a sensitivity of 82% and specificity of 69%, meaning it missed some fractures and misidentified some normal cases.
  • The radiologists performed better overall, with a sensitivity of 92% and specificity of 88%, indicating they were more accurate in diagnosing the fractures.
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Background: Image-guided percutaneous lung biopsy (PLB) may lead to major complications requiring hospitalization. This study aims to evaluate the rate of major PLB complications and determine a predictive computed tomography (CT) score to define patients requiring hospitalization due to these complications.

Methods: This single-center retrospective study included all PLBs performed from July 2019 to December 2020 in Nimes University Hospital, France.

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Background: Inception cohorts aim to describe chronic diseases from diagnosis and over years of follow-up. Axial spondyloarthritis (axSpA) diagnosis might be challenging during the first years of the disease. Thus, identifying the features that will be associated with a confirmed diagnosis over time is key.

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Introduction: The treatment of acute type B aortic dissection (ATBAD) is currently a challenge for vascular surgeons, because of the early morbidity and mortality rates and the high risk of late aortic events up to 50% at 5 years. This study presents the initial outcomes of ATBAD treatment using optimal medical therapy alone or combined with proximal entry tear stent-graft coverage. Additionally, it provides an analysis of the evolution of the aortic diameter and its clinical consequences during the chronic phase in each group.

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The impact of chronic urticaria on work has been scarcely reported, whereas its peak incidence is between the ages of 20 and 40. The aim of this study was to assess the occupational impact of chronic urticaria and its treatment, by combining objective and patient-reported data. A monocentric observational study was performed using questionnaires over a 1-year period from 2021 to 2022 in chronic urticaria patients who were in a period of professional activity and agreed to participate.

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Objectives: This study aimed to evaluate the 10-year clinical outcome of patients with recent-onset axial spondyloarthritis (axSpA).

Methods Study Design: The DESIR cohort is an inception cohort of axSpA patients.

Methods Diagnosis And Management: The diagnosis and management of patients were based on the decision of the treating rheumatologist.

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Article Synopsis
  • Aging leads to a decrease in lean tissue mass (LTM) and muscle strength in women with obesity, contributing to sarcopenic obesity (SO).
  • The study found that as women aged, there was a redistribution of LTM and fat mass (FM) from the limbs to the trunk, and physical performance metrics like muscle strength and function also declined.
  • Despite these changes, the prevalence of women with obesity affected by sarcopenic obesity remained low, at 15% or less, even among those over 60 years old.
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Study Objective: During the COVID crisis, pre-anesthesia teleconsultations were widely used leading to savings in time and money. However, the non-inferiority of this system has not yet been evaluated.

Design: Prospective, randomized, controlled, single-blind non-inferiority study.

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  • Spinal cord injury (SCI) leads to bone loss and higher fracture risk, prompting a study to assess the impact of whole-body vibration (WBV) on bone health in chronic SCI patients.
  • Fourteen participants were split into two groups: one receiving WBV treatment twice a week for six months and the other as a control.
  • After six months, there were no significant changes in bone density or biological markers in either group, but the WBV group did experience a notable reduction in body fat compared to controls, suggesting the need for further investigation into different WBV approaches.
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Background: The study aimed to determine the level of agreement between patients with epilepsy and their proxies when assessing psychiatric comorbidities, sleep disorders, and medication adherence using standardized questionnaires.

Methods: This agreement study is an ancillary analysis of the PRERIES study, a matched case-control study exploring SUDEP risk factors. Controls aged 15 years and older, with active epilepsy or in remission for less than 5 years were recruited between 01/01/2011 and 03/31/2019.

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Spinal cord injury (SCI) induces severe losses of trabecular and cortical volumetric bone mineral density (vBMD), which cannot be discriminated with conventional dual-energy X-ray absorptiometry (DXA) analysis. The objectives were to: (i) determine the effects of SCI on areal BMD (aBMD) and vBMD determined by advanced 3D-DXA-based methods at various femoral regions and (ii) model the profiles of 3D-DXA-derived parameters with the time since injury. Eighty adult males with SCI and 25 age-matched able-bodied (AB) controls were enrolled in this study.

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Aim: To evaluate the real-life diagnosis and therapeutic means of Charcot Neuroosteoarthropathy (CN) in French-Belgian diabetic foot expert centers.

Methods: We collected clinical characteristics, results of exams and therapeutic pathways of consecutive adult patients with diabetic osteoarthropathy seen in consultation or hospitalization from January 1 to December 31, 2019 in 31 diabetic foot expert centers. The primary outcome was to describe the diagnostic and management methods for CN according to patient clinical characteristics, the clinical-radiological characteristics of acute and chronic CN and discharge means.

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Introduction: Obstetric anal sphincter injuries (OASIs) at the time of childbirth can lead to serious consequences including anal incontinence, dyspareunia, pain and rectovaginal fistula. These types of lesions and their incidence have been well studied after cephalic presentation deliveries, but no publications have specifically addressed this issue in the context of vaginal breech delivery. The goal of our study was to evaluate the incidence of OASIs following breech deliveries and compare it with cephalic presentation births.

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Article Synopsis
  • The study evaluated a deep learning image reconstruction algorithm (DLR) against an iterative reconstruction algorithm (IR) to see which provides better image quality and clarity of liver metastases.
  • It involved 30 patients with liver metastasis, measuring various metrics like image noise and quality through established scales by radiologists.
  • Results showed that the DLR algorithm significantly reduced image noise compared to IR, especially at the Smooth and Smoother levels, which also scored highest in overall image quality and lesion visibility.
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Background: A nation-wide study recently published the dose reference levels for the main CT-guided interventional procedures in 5001 patients. We assessed the impact of patient's age, sex and targeted organ on the patient dose during thoracic and abdominopelvic biopsies and punctures/drainages.

Patients And Methods: Data were extracted from the previous nationwide study.

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To evaluate the rates of serious complications and reoperation for recurrence following sacrospinous ligament fixation (SSLF) for apical pelvic organ prolapse. This was a national registry ancillary cohort comparative study. The VIGI-MESH registry includes data from 24 French health centers prospectively collected between May 2017 and September 2021.

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Background: Percutaneous cryoablation with liquid nitrogen is a new technique being used in the treatment of some malignant tumors. Our objective was to assess its feasibility in the ablation of tumor lesions of various sizes and locations.

Methods: This retrospective, monocentric study included all consecutive patients who underwent percutaneous cryoablation with liquid nitrogen between December 2019 and March 2021.

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The prevalence of sarcopenia in patients with obesity varies according to the definition used. The purpose of our study was to: (i) determine the prevalence of sarcopenia in terms of lean tissue mass in older women with obesity using the current cut-offs, (ii) redefine a specific cut-off for low lean tissue mass (LLTM), and (iii) re-determine the prevalence of LLTM using this new cut-off. Appendicular lean mass (ALM) and the ALM index [ALM/height: ALMI(h)] and ALMI/body mass index [ALMI(BMI)] were determined in 791 women with or without obesity.

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Article Synopsis
  • * Researchers analyzed data from 62 SUDEP cases and 620 control patients, identifying seven key predictors of SUDEP, including seizure frequency and sleep-related seizures.
  • * The final SUDEP-CARE score ranges from -1 to 8, demonstrating high sensitivity and specificity for predicting SUDEP, with a threshold of 3 indicating a higher risk; further validation and enhancement of the score are necessary.
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Purpose: The purpose of this multicenter study was to evaluate the clinical success at three months of prostate artery embolization (PAE), assess PAE safety in centers with various experiences and identify factors associated with PAE success.

Patients And Methods: This multicenter, retrospective study included patients who underwent PAE for lower urinary tract symptoms (LUTS) including those with indwelling urinary catheter. PAE clinical success was defined as either 25% improvement of the International Prostate Symptom Score (IPSS) or 1-point improvement of quality of life (QoL) score, or catheter removal at three months.

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Objectives: Several studies have suggested a strong relationship between the number of peripherally inserted central catheter (PICC) lumens and the risk of complications. The purpose of this study is to evaluate the impact of the intervention of a clinical pharmacist (CP) on the number of lumens of PICC inserted and assess PICC-related complications.

Method: This prospective monocentric study included all consecutive patients from 5 different units who underwent PICC insertions from September 2017 to March 2018.

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Article Synopsis
  • The study found a link between anticholinergic medications for overactive bladder and a higher risk of developing dementia in older adults.
  • Researchers analyzed data from a large database, comparing patients with dementia to matched controls, and noted that increased use of these medications correlates with a greater risk of dementia.
  • Notably, drugs like oxybutynin and solifenacin showed a significant association with dementia risk, whereas trospium did not, suggesting the need for careful consideration of treatment choices in older patients.
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