Publications by authors named "Serra Akar"

Prolidase is a manganese (Mn)-dependent cytosolic exopeptidase that degrades imidodipeptides with C-terminal proline or hydroxyproline. Prolidase recycling from imidodipeptides plays a critical role in collagen resynthesis and extracellular matrix (ECM) remodelling. Following an increase in gonadotropins, ovarian and follicular collagen undergo substantial degradation.

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Objective: To evaluate the oncologic outcomes of endometrial cancer metastasis to the adrenal gland and kidney, based on a case study and review of the literature.

Material And Methods: A systematic review of the medical literature was performed to identify articles about metastatic endometrial cancer to the adrenal gland and kidney from 1975 until 2021.

Results: A 55-year-old female patient was admitted to our center.

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Introduction: The etiologies of diminished ovarian reserve (DOR) are still poorly understood, and many factors such as age, autoimmunity, genetics, idiopathicity, iatrogenesis, and oxidative stress (OS) play a role. Oxidative cellular damage increases following reactive oxygen species (ROS)-induced aging. This is the first study to evaluate the serum and follicular fluid (FF) thiol/disulfide homeostasis in patients under 35 years of age with DOR undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

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Unlabelled: The relationship between oxidative stress and unexplained infertility (UEI) has not been studied in detail. This is the first study to evaluate dysfunctional high-density lipoprotein (HDL) by the myeloperoxidase (MPO) and paraoxonase (PON) ratio to investigate the role of oxidative stress in UEI.

Materials And Methods: Patients with UEI (study group, = 40) and male factor infertility (control group, = 36) were included in this prospective study.

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Article Synopsis
  • The study focuses on analyzing Pap smear results that show atypical glandular cells, not otherwise specified (AGC-NOS), to identify potential cervical and endometrial lesions.
  • A total of 254 women who had AGC-NOS results and subsequently underwent colposcopy were reviewed, revealing that around 27.6% had premalignant or malignant lesions, including 6.7% with actual malignancies.
  • The findings suggest that careful evaluation of patients with AGC-NOS is crucial, with a recommendation for colposcopic examination and potential endometrial sampling to detect any underlying cancers.
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In this retrospective study, patients with epithelial gynaecologic cancer with pulmonary recurrence (PR) were evaluated from five national gynaecologic oncology clinics. Patients with a diagnosis of primary endometrial, ovarian/fallopian tube/peritoneal, cervical or vaginal/vulvar tumours who developed an initial PR were included in the study A total of 122 patients were included in the study. The median follow-up time after recurrence was 7.

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We investigated the association between preoperative ratios of inflammatory markers and the prognosis in patients with invasive cervical cancer (CC). In this single-centre study, we retrospectively enrolled 163 CC patients who underwent radical hysterectomy between February 2008 and October 2018. Among the evaluated ratios, a high neutrophil-to-lymphocyte ratio (N/L) was significantly associated with deep stromal invasion and tumour size larger than 2 cm, whereas a high M/L was significantly related to advanced-stage CC (IB3-IIIC2), lymphatic metastasis (total) and pelvic lymph node metastasis (= .

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The molecular pathways involved in the development of vulvar squamous cell carcinoma (SCC) cancer are not completely known. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme associated with tumorigenesis and metastasis in a variety of cancers. Its role in vulvar cancer has not been studied, previously.

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  • The study aimed to assess the incidence of unexpected leiomyosarcoma (LMS) in patients who had surgery for leiomyomas in Konya province, finding an incidence rate of 0.56% (1 in 176 surgeries), which is higher than reported in existing literature.
  • The researchers analyzed surgery data from eight hospitals between January 2012 and January 2019, discovering 21 cases of unexpected LMS out of 3703 patients, alongside 6 other malignant tumors in the cohort.
  • Given the higher incidence of LMS and ongoing debates around surgical procedures, it emphasizes the need for improved preoperative detection methods to better manage patient care and calls for further studies into tumor biology for accurate diagnosis.
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  • The study aimed to analyze the clinical and pathological characteristics, treatment methods, and outcomes for patients with malignant struma ovarii, using a systematic review of literature and a case study.
  • The research reviewed 178 cases and revealed that the overall survival rate was high at 91%, but factors like younger age and specific tumor characteristics were linked to poorer survival outcomes.
  • Radioactive iodine treatment before treatment failure significantly improved progression-free survival, highlighting the importance of tailored treatment strategies based on individual tumor histology and patient factors.
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  • The study compared the effectiveness of two methotrexate (MTX) treatment regimens—weekly MTX and an 8-day MTX-folinic acid (MTX-FA) regimen—in patients with low-risk gestational trophoblastic neoplasia (GTN).
  • Out of 73 patients, the MTX-FA 8-day regimen showed a higher complete response rate (83%) compared to the weekly MTX regimen (60%).
  • The presence of lung metastasis was identified as a significant independent risk factor for treatment resistance, indicating that the MTX-FA 8-day regimen is generally more effective, especially for patients with higher FIGO risk scores.
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Objective: To evaluate the clinico-pathological patient features, prognostic factors, treatment options and outcomes of peripheral nodal recurrence (PNR) of endometrial cancer (EC).

Material And Methods: The data of nine patients with PNR of EC from two institutions were reviewed. The electronic literature was reviewed from 1972 to May 2018 to identify articles about PNR in EC.

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The anti-proliferative effects of 5-methylquinolinium (5MQ) of nicotinamide N-methyltransferase (NNMT) have not been previously investigated on a cervical cancer cell line. NNMT is a metabolic enzyme that is correlated with tumour progression and metastasis. 5MQ is a small molecule inhibitor of NNMT.

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Objective: The aim of this study was to evaluate clinicopathological features, oncological outcome and prognostic factors for recurrence in advanced stage uterine serous carcinoma (USC) patients.

Methods: Patients with 2009 International Federation of Gynecology and Obstetrics stage III&IV uterine serous carcinoma were enrolled from 4 gynecologic oncology centers and a study group was created. Response to therapy was evaluated according to the WHO criteria.

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  • - This study explored the link between striae gravidarum (stretch marks) and preterm delivery among pregnant women, analyzing various factors related to the severity of striae.
  • - Conducted from November 2018 to February 2019, the study included 292 women and found that those in the preterm labor group generally had lower severity scores of striae and specific patterns of striae distribution compared to those who delivered at term.
  • - Key findings indicated that the presence of striae on breasts was associated with preterm delivery, while no significant differences in pregnancy length were noted across different severity levels of striae.
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Ovarian cancer is the fifth leading cause of cancer-related mortality in women. Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme and there is growing evidence to suggest that it plays an important role in cancer progression. This is the first study to examine the expression of NNMT in serous ovarian cystadenomas, serous borderline tumours, low grade serous carcinomas (LGSC) and high grade serous carcinomas (HGSC) and investigate the potential independent association of NNMT expression with survival.

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Background/aim: Nicotinamide N-methyltransferase (NNMT) is an enzyme that is overexpressed in malignancies. NNMT expression has not been previously studied in endometrial cancer (EC). Increased phospho-Akt (pAkt) levels in response to NNMT overexpression have been reported in in vitro studies of different cancer types.

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Background: Endometrioid endometrial cancer is the most common histological subtype of endometrial adenocarcinoma. In the FIGO grading scheme, both architectural and nuclear grade are taken into consideration. However, the specific impact of solid growth alone on endometrioid endometrial adenocarcinoma outcome is not well documented.

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Introduction: Subclinical inflammation markers play a significant role in hyperemesis gravidarum (HEG). Simple hematological markers such as mean platelet volume (MPV), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), plateletcrit (PCT), and platelet-to-lymphocyte ratio (PLR) have been shown to reflect inflammatory burden and disease activity in several disorders. Ketonuria is a parameter used in the diagnosis of severe HEG, but its correlation with disease severity remains controversial.

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Article Synopsis
  • Nicotinamide N-methyltransferase (NNMT) is an enzyme linked to various cancers and treatment resistance, and its role in cervical cancer hasn't been explored until now.
  • This study evaluated NNMT expression in 61 cases of cervical squamous cell carcinoma (SCC) and found that it was significantly higher in SCC compared to benign and pre-cancerous tissues.
  • Higher NNMT levels were associated with advanced cancer stages and the presence of metastatic lymph nodes, suggesting that NNMT could serve as a potential therapeutic target and prognostic indicator in cervical cancer.
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Purpose: The objective of this study was to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR) compared to CA-125 in patients with endometriomas.

Methods: This study was designed as a retrospective comparative study. A total of 807 women who underwent surgery due to benign ovarian cysts between January 2008 and January 2013 were included in the study.

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Vulvar haematoma as a complication of laparoscopic adnexal surgery has rarely been reported. Indeed, to our knowledge, there are only two case reports describing postlaparoscopic vulvar haematoma in the literature. Although complications associated with laparoscopy are mostly related to bowel or retroperitoneal vessel injury, vulvar haematoma may seldom develop.

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