Anticancer Effects of Urtica Dioica in Breast Cancer.

Objective: The goal of this study is to look into the antiproliferative capabilities of Urtica Dioica (UD) on breast cancer.

Methods: The cytotoxicity of UD extracts against breast cancer cell lines was investigated. Flow cytometry analyses were used to investigate in vitro apoptosis of breast cancer cells using Annexin V labeling.

Effect of Strontium Ranelate on Condylar Growth during Mandibular Advancement in Rats.

Objective: Strontium ranelate (SR), unlike other anti-osteoporotic agents, might not only prevent bone resorption but also might induce bone formation. The aim of this experimental study was to evaluate the effects of systemic SR on condylar growth during mandibular advancement (MA) in growing rats.

Methods: Fifty-six, 8-week-old Wistar male rats weighting 160-190 g were randomly divided into four groups; one control (n=14) and three experimental (n=14).

A digital image analysis study on the disintegration kinetics of reticular fibers in the ethylene glycol-induced rat liver tissue.

Ethylene glycol (EG), the raw material of polyethylenterephthalate, which is the most consumed plastic in the world, has low toxicity, but its metabolites are toxic. EG metabolites can cause acidosis, fibrosis, and eventually cirrhosis in the liver. This study aimed to investigate the effect of EG on rat liver and to determine the quantitative values of the disintegration of reticular fibers (RF) in the liver with the dose duration and to investigate the changes by digital image analysis (DIA).

Effects of diabetes on apoptosis and mitosis in rat hippocampus.

Diabetes contributes to neurological dysfunction including peripheral nerve diseases, stroke and dementia. We investigated the effects of diabetes on apoptosis and mitosis in the hippocampal CA1 region. Rats were given diabetes by injection of streptozotocin (STZ).

A study of digital image analysis on the acrylamide derivative monomers induced apoptosis in rat cerebrum.

Nowadays, apoptosis is mostly evaluated visually in histological studies. By using the quantitative digital image analysis, this study aimed to investigate the effect of acrylamide-based monomers (acrylamide [AAm], methacrylamide [MAAm], N-isopropylacrylamide [NIPAm]) on the cerebrum tissues in rats, which are the most common water-soluble monomers in the production of polymeric hydrogels used as biomaterials. The Wistar albino rats weighing ~220-240 g were divided into control and three test groups.

Chemopreventive effects of hydatid disease on experimental breast cancer.

Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer.

Antitumoral effects of Allium sivasicum on breast cancer in vitro and in vivo.

This work aims to investigate the antiproliferative properties of Allium sivasicum (AS) on breast cancer. AS extracts were studied for cytotoxicity against the breast cancer cell lines. In vitro apoptosis studies of breast cancer cells were performed by annexin V staining in flow cytometry analyses.

Antitumoral effects of Melissa officinalis on breast cancer in vitro and in vivo.

Background: There is a long standing interest in the identification of medicinal plants and derived natural products for developing cancer therapeutics. Here we investigated the antiproliferative properties of Melissa officinalis (MO) from Turkey on breast cancer.

Methods: MO extracts were studied for cytotoxicity against breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231).

The bone-healing effect of a xenograft in a rat calvarial defect model.

Bone grafts have been widely used to fill osseous defects in medicine, dentistry, and periodontology. The purpose of this study was to investigate the effects of a xenograft (Unilab Surgibone) on experimentally created parietal bone defects in rats. To this end, 14 rats were employed in the present study and in each of them, 5-mm-diameter defects were created on the parietal bone.

Histological findings of long-term healing of the experimental defects by application of a synthetic biphasic ceramic in rats.

Calcium phosphate ceramics are generally biocompatible and can develop interactions with human recipient bone. Therefore, they can be widely used in the field of periodontology and dentistry. The purpose of this investigation was to assess the long-term histological bone healing results of experimentally created critical size parietal bone defects in rats.

Assessment of the effect of a biphasic ceramic on bone response in a rat calvarial defect model.

Calcium phosphate ceramics are being extensively used for orthopedic, periodontal, and dental applications. This study aimed to assess the effect of a biphasic ceramic such as Ceraform on the osteogenesis in a rat calvarial defect model. 20 Wistar rats were enrolled in the study.

Positive effects of phenytoin on experimental colonic anastomoses.

Background And Aims: Anastomotic dehiscence following colorectal surgery is a significant cause of morbidity and mortality. Phenytoin has wound-healing promoting and collagenase inhibitory effects. This study assessed these effects on healing of experimental colonic anastomoses in a rat model.