Publications by authors named "Serov Yuri"
Article Synopsis
- This study aims to examine the histopathology and outcomes in patients with retinoblastoma who underwent eye enucleation and had neovascular glaucoma (NVG).
- The research included 1,420 total cases from five continents, revealing that 16% of patients with NVG were often at higher risk of severe histopathological findings.
- The findings indicate that NVG is linked to more aggressive forms of the disease and a higher chance of metastasis, emphasizing the need for careful monitoring and treatment in these cases.
Purpose: To compare the clinical outcomes of children with unilateral retinoblastoma (Rb) and high-risk histopathology features (HRHF) following upfront enucleation with/without adjuvant chemotherapy, and investigate cases locally considered non-HRHF but converted to a standardized HRHF definition.
Design: Retrospective multinational clinical cohort study.
Methods: Children with Rb who presented to 21 centers from 12 countries between 2011-2020, and underwent primary enucleation were recruited.
Article Synopsis
- The study aimed to analyze high-risk histopathological features in eyes with retinoblastoma (RB) after enucleation and compare patient outcomes globally.
- A total of 1,426 RB cases were reviewed, revealing significant differences in histopathological features across continents, with Asia showing the highest rates of massive choroidal invasion and optic nerve invasion.
- The findings indicated that patients from South America and Asia faced greater risks of tumor recurrence, systemic metastasis, and mortality compared to those from Australia, Europe, and North America.