Clinical and therapeutical aspects of cold urticaria (urticaria a frigore).

A new drug with inhibitory properties on the Mast Cell degranulation, Ketotifen, was administered in 87 patients suffering from idiopathic urticaria a frigore (iUF). The first group (A), with 52 patients effectuated prophylactic management for 4 months with Ketotifen (K) (2 mg/day) and Clemastine (C) (2 mg/day) according to the double blind crossover method. Both the drugs were administrated in stages of 2 months each.

Imminent shock; a useful diagnosis in drug pathology.

A research has been carried out on a total of 121 persons with survival post-drug shock (DS), which registered 192 DS. Mention should be made of their predominance in the feminine sex (85 per cent) and their maximum frequency between the ages of 21-50 (average age 34). DS was the first adverse reaction to drugs in 71 per cent of the cases.

[Experience in the field of microbial allergic asthma].

The present paper reports on the effect of prolonged microbial hyposensitization applied in 206 cases of microbial allergic asthma in comparison to 95 asthmatic patients of the same category in which this treatment was not applied; improvement was obtained in 78% of the former lot as against 17% in the latter. The quanlity of the improvement obtained and the dependence of the results upon the various diagnostic criteria used are discussed. Microbial hyposensitization has proved efficient in asthmatic patients although its mechanism of action is not yet known, nor the difference that exists from this point of view with the current microbial vaccination.

The criterion of the inhalation test to allergens at establishing specific hyposensitizing in allergic asthma.

The experience we had in our casuistics as regards 1,000 asthmatics, demonstrates the positive inhalation test (IT) to allergens, only in about 40% of the asthmatics having positive cutaneous test (CT). The technic for determination has used the FEV1 criterion. We correlated the data of the anamnesis (A), CT and IT.