Alleviative effect of scopolamine‑induced memory deficit via enhancing antioxidant and cholinergic function in rats by pinostrobin from (L.).

Pinostrobin, a key bioactive compound found in the medicinal plant (L.), has been noted for its beneficial biological properties including antioxidant, anti-inflammation, anti-cancer and anti-amnesia activities. In view of this, the present study purposed to evaluate the neuroprotective potential of pinostrobin in reversing scopolamine-induced cognitive impairment involving oxidative stress and cholinergic function in rats.

Pinostrobin alleviates chronic restraint stress‑induced cognitive impairment by modulating oxidative stress and the function of astrocytes in the hippocampus of rats.

Chronic stress has been recognized to induce the alterations of neuronal and glial cells in the hippocampus, and is thus implicated in cognitive dysfunction. There is increasing evidence to indicate that natural compounds capable of exerting neuroprotective and antioxidant activities, may function as potential therapeutic agents for cognitive impairment. The present study examined the neuroprotective effects of pinostrobin from (L.

Dipterostilbenosides A and B, oligostilbene glycosides from Dipterocarpus tuberculatus.

From the chemical investigation of the methanolic extract of the roots of the Thai dipterocarp, Dipterocarpus tuberculatus, two new oligostilbene glycosides, dipterostilbenes A (1) and B (2), were isolated together with four known stilbenes. Their structures and relative configurations were determined on the basis of spectroscopic data. From an evaluation of cytotoxic activity against KB and HeLa cell lines, α-viniferin (5) and (-)-hopeaphenol (6) showed potent activity, but less than that of doxorubicin.

Highly potent oligostilbene sbLOX-1 inhibitor from Gnetum macrostachyum.

Isolated oligostilbenes from G. macrostachyum exhibited sbLOX-1 inhibitory activity with IC50 values ranging from 0.14-11.

Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.

During the screening of natural chemicals that can reverse multidrug resistance in human A549 lung cancer cells resistant to etoposide (A549RT-eto), we discovered that Feroniellin A (FERO), a novel furanocoumarin, shows toxicity toward A549RT-eto cells in a dose- and time-dependent manner. FERO reduced the expression of NF-κB, leading to downregulation of P-glycoprotein (P-gp), encoded by MDR1, which eventually sensitized A549RT-eto cells to apoptosis. FERO specifically diminished transcription and promoter activity of MDR1 but did not inhibit the expression of other multidrug resistance genes MRP2 and BCRP.

Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis.

A pair of new isomeric indole alkaloids, naucleaorals A (1) and B (2) were isolated from the roots of Nauclea orientalis. The structures of compounds 1 and 2 were fully characterized using spectroscopic data, and were tested for their cytotoxicity (HeLa and KB cells) and antimalarial activity. Compound 1 showed significant cytotoxicity to HeLa cells with an IC(50) value of 4.

Antioxidant xanthones from Cratoxylum cochinchinense.

A new xanthone named cratoxylumxanthone A (1), together with five known compounds: dulcisxanthone B (2), alpha-mangostin (3), beta-mangostin (4), 2-geranyl-1,3,7-trihydroxy-4-(3-methylbut-2-enyl)xanthone (5) and tectochrystin (6), was isolated from Cratoxylum cochinchinense stems. The structure of new compound was characterized by 1D and 2D NMR techniques. The isolated compounds showed free radical scavenging against DPPH and lipid peroxidation inhibition.

Feroniellin B, a new highly potent human platelet aggregation inhibitor from Feroniella lucida.

Human platelet aggregation inhibition by coumarins isolated from Feroniella lucida roots extract was investigated. Of 11 coumarins examined, feroniellin B highly inhibited platelet aggregation induced by ADP with an IC(50) value of 0.287 mm while the standard drug ibuprofen displayed this inhibition with an IC(50) value of 11.

A novel furanocoumarin from Feroniella lucida exerts protective effect against lipid peroxidation.

The protective effect of Feroniella lucida against lipid peroxidation was investigated. Bioassay-guided separation using rat brain as a model led to the isolation of a new antioxidant furanocoumarin named feroniellamin (6) along with five known coumarins. The structure of 6 was characterized by interpretation of spectroscopic data.