Publications by authors named "Serkan Yigitkan"
The importance of L. species, being used in traditional medicine, in the scientific world is increasing day by day. species are plants that have been used in the treatment of many diseases for a long time and have healing properties.
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- Ethnopharmacology plays a crucial role in identifying natural drug candidates, with sage being a prominent medicinal plant known for its memory-enhancing properties in European folk medicine.
- Recent research highlights various species of sage that have exhibited positive effects on cognitive dysfunction, particularly in Alzheimer's disease, based on preclinical studies.
- Clinical evidence supports the effectiveness of specific sage preparations, but the need for larger, longer-term studies with standardized extracts is emphasized to validate these findings.
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- HMG-CoA reductase is a crucial enzyme for cholesterol production and a key target for treating high cholesterol levels.
- The study evaluated the inhibitory effects of extracts from Vahl. roots and aerial parts, with the root extract showing significant inhibition at 71.97% when tested at 100 µg/mL.
- Further analysis led to isolating 10 known compounds, with 7-acetoxyhorminone demonstrating the strongest inhibition (84.15%) and effective binding to the enzyme's active site via molecular docking studies.
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- * The research found that seed extracts exhibited higher antioxidant activity compared to leaf and pulp extracts, with the Banazı Siyahı variety showing the strongest activity across all tested methods.
- * Additionally, certain compounds like catechin and isoquercitrin were identified in significant amounts, suggesting that Banazı Siyahı and Kerküş varieties could be important for pharmaceutical and food applications.
Gundelia species are known as "Kenger-kereng dikeni" in Anatolia, and their aerial parts are consumed as food. Also, roots and seeds (disseminules) of the Gundelia species are used to prepare gum and coffee. The chemical contents of ethanol and hexane extracts of disseminules of 17 Gundelia species, 13 of them are endemic, were studied using LC/MS/MS and GC/MS.
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