Comparison of Drug Delivery Systems with Different Types of Nanoparticles in Terms of Cellular Uptake and Responses in Human Endothelial Cells, Pericytes, and Astrocytes.

: The key components of the blood-brain barrier (BBB) are endothelial cells, pericytes, astrocytes, and the capillary basement membrane. The BBB serves as the main barrier for drug delivery to the brain and is the most restrictive endothelial barrier in the body. Nearly all large therapeutic molecules and over 90% of small-molecule drugs cannot cross the BBB.

Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells.

Glioblastoma, with a low survival rate, is an aggressive and difficult-to-treat lethal type of brain cancer. Indomethacin (IND), a non-steroidal anti-inflammatory drug, has antitumoral activity in many cancers, including gliomas. However, its poor aqueous solubility is a critical issue.

Antimicrobial and Antibiofilm Activity of Green Synthesized Silver Nanoparticles by Using In Vitro Grown Aloe vera L.

In this study, in vitro grown Aloe vera L. tissues were used for AgNP synthesis. Adventitious root and callus tissues were grown in MS medium containing 1 mg/L IAA and 1 mg/L NAA.

Achieving bifacial photovoltaic performance in PTB7-based organic solar cell by integrating transparent contact for emerging semi-transparent applications.

In this study, the design, fabrication and detailed analysis of semi-transparent bifacial organic solar cells (ST-OSC) based on MoO/Ag/WO (10/d/d nm) dielectric/metal/dielectric (DMD) transparent contact system integrated with PTB7 polymer were investigated. The study emphasizes the importance of designing transparent contact systems to optimize the solar cells' transparency (average visible transmittance, AVT), color rendering (color rendering index, CRI), efficiency (power conversion efficiency, PCE), and bifaciality. The performance of three distinct configurations was examined in the AVT (47.

The Effects of Cross-Linking Agents on the Mechanical Properties of Poly (Methyl Methacrylate) Resin.

Cross-linking agents are incorporated into denture base materials to improve their mechanical properties. This study investigated the effects of various cross-linking agents, with different cross-linking chain lengths and flexibilities, on the flexural strength, impact strength, and surface hardness of polymethyl methacrylate (PMMA). The cross-linking agents used were ethylene glycol dimethacrylate (EGDMA), tetraethylene glycol dimethacrylate (TEGDMA), tetraethylene glycol diacrylate (TEGDA), and polyethylene glycol dimethacrylate (PEGDMA).

In-depth analysis on PTB7 based semi-transparent solar cell employing MoO/Ag/WO contact for advanced optical performance and light utilization.

Novel semi-transparent organic solar cells (ST-OSC) can be designed with high average visible transmittance (AVT) while at the same time exhibiting superior photovoltaic performance. This reach requires their design to be based not only on conventional window applications but also on functional industrial applications that require exceptional optical performance. In ST-OSC, high AVT can be achieved by photonic-based dielectric/metal/dielectric (DMD) transparent contact engineering.

Enhancement of color and photovoltaic performance of semi-transparent organic solar cell via fine-tuned 1D photonic crystal.

Semi-transparent organic solar cells' (ST-OSCs) photovoltaic and high optical performance parameters are evaluated in innovative applications such as power-generating windows for buildings, automobiles, and aesthetic designs in architectural and industrial products. These parameters require the precision design of structures that optimize optical properties in the visible region and aim to achieve the required photon harvest in UV and IR. These designs can be realized by integrating wavelength-selective photonics-based systems into ST-OSC to increase localized absorption in wavelengths greater than 600 nm and NIR and provide modifiable optical properties.

Blood-brain barrier targeted delivery of lacosamide-conjugated gold nanoparticles: Improving outcomes in absence seizures.

Objective: Most currently available antiepileptics are not fully effective in the prevention of seizures in absence epilepsy owing to the presence of blood-brain barrier (BBB). We aimed to test whether binding an antiepileptic drug, lacosamide (LCM), to glucose-coated gold nanoparticles (GNPs) enables efficient brain drug delivery to suppress the epileptic activity in WAG/Rij rats with absence epilepsy.

Methods: In these animals, intracranial-EEG recording, behavioral test, in vivo imaging of LCM and LCM-GNP conjugate distribution in the brain, inductively coupled plasma mass spectrometry analysis, immunofluorescence staining of glucose transporter (Glut)- 1, glial fibrillary acidic protein (GFAP), and p-glycoprotein (P-gp) and electron microscopy were performed.

Protective Effects of Intranasally Administrated Oxytocin-Loaded Nanoparticles on Pentylenetetrazole-Kindling Epilepsy in Terms of Seizure Severity, Memory, Neurogenesis, and Neuronal Damage.

Pentylenetetrazole (PTZ)-induced kindling is an animal model for studying human temporal lobe epilepsy (TLE), which is characterized by alterations of hippocampal neurons and memory. Although the intranasal (IN) administration of oxytocin (OT) has limited efficiency, nanoparticles (NPs) are a promising candidate to deliver OT to the brain. However, there are very limited data on epilepsy research about oxytocin-loaded nanoparticles (NP-OTs).

Adsorption of rutin from olive mill wastewater using copolymeric hydrogels based on N-vinylimidazole: Kinetic, equilibrium, and thermodynamics assessments.

Olive mill wastewater, also known as olive wastewater, contains biologically active components with various beneficial effects on health. The development of novel adsorbent materials for the recovery of these biologically active substances is important area of research. In this study, copolymeric hydrogels based on N-vinylimidazole (VIm), a new material that has never been used as an adsorbent in the separation of phenolic components, were synthesized.

Design and fabrication of a semi-transparent solar cell considering the effect of the layer thickness of MoO/Ag/MoO transparent top contact on optical and electrical properties.

We conducted the present study to design and manufacture a semi-transparent organic solar cell (ST-OSC). First, we formed a transparent top contact as MoO/Ag/MoO in a dielectric/metal/dielectric (DMD) structure. We performed the production of an FTO/ZnO/P3HT:PCBM/MoO/Ag/MoO ST-OSC by integrating MoO/Ag/MoO (10/[Formula: see text]/[Formula: see text] nm) instead of an Ag electrode in an opaque FTO/ZnO/P3HT:PCBM/MoO/Ag (-/40/130/10/100 nm) OSC, after theoretically achieving optimal values of optical and electrical parameters depending on Ag layer thickness.

Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery.

An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b -MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-b - poly(ε-caprolactone) diblock polymers (MPEG-b -PCL) as the shell building block, was designed. The synthesized polymers were characterized with FTIR, 1 H NMR, 13 C NMR, and GPC analysis. Monodisperse HPAE-PCL-b - MPEG nanoparticles with dimensions of < 200 nm and polydispersity index of < 0.

Targeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats.

Temporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures, and currently available drugs may fail to provide a thorough treatment of the patients. The present study demonstrates the utility of glucose-coated gold nanoparticles (GNPs) as selective carriers of an antiepileptic drug, lacosamide (LCM), in developing a strategy to cross the blood-brain barrier to overcome drug resistance. Intravenous administration of LCM-loaded GNPs to epileptic animals yielded significantly higher nanoparticle levels in the hippocampus compared to the nanoparticle administration to intact animals.

Folic acid-modified methotrexate-conjugated gold nanoparticles as nano-sized trojans for drug delivery to folate receptor-positive cancer cells.

Methotrexate (MTX), an analog of folic acid (FA), is a drug widely used in cancer treatment. To prevent its potential toxicity and enhance therapeutic efficacy, targeted drug delivery systems, especially nanotechnology-folate platforms, are a central strategy. Gold nanoparticles (AuNPs) are promising candidates to be used as drug delivery systems because of their small particle sizes and their inertness for the body.

A facile polymerisation of magnetic coal to enhanced phosphate removal from solution.

Globally, there are increased threats to available freshwater resources due to pollution, climate change, and increased demand from population growth. Phosphorus is one of the essential nutrients required for animal and plant growth. However, when it is released into freshwater resources in excess amounts, it can become a pollutant through eutrophication.