Publications by authors named "Serigne Ousmane Mbacke Diaw"
Background: The emergence of -deleted parasites threatens histidine-rich protein 2 (HRP2)-based malaria rapid diagnostic test (RDT) performance. RDTs targeting () lactate dehydrogenase (LDH) may address current product limitations and improve case management.
Objectives: To evaluate the performance and usability of three LDH-based RDTs in febrile patients.
In malaria endemic countries, non-falciparum species are often mixed with Plasmodium falciparum in patients with uncomplicated malaria, and their contribution to malaria severity and death is poorly studied. This study assesses the contribution of non-falciparum species to malaria severity in three regions of Senegal with the highest malaria incidence.We analysed 617 blood samples obtained between 2015 and 2021 from confirmed malaria patients at health facilities in Kedougou, Kolda and Tambacounda in Senegal.
View Article and Find Full Text PDFObjectives: In low malaria transmission areas, the elimination of the disease has been hampered partly by the existence of a reservoir of subpatent Plasmodium falciparum infections within communities. This reservoir, often undetected, serves as a source of parasites and contributes to ongoing transmission and clinical malaria cases.
Methods: This study, spanning a period of 9 years from June 2014 to December 2022, examined individual variations and long-term subpatent P.
Background: The first discovery of infections in Senegal used archived patients' sera in place of blood pellet, the preferred specimen for the molecular diagnosis of species. The present study assessed the reliability of detecting DNA in plasma in comparison to blood pellet from the same patient's samples.
Methods: A total of 616 blood samples obtained from febrile patients living in Kolda (2015 and 2020), Tambacounda (2017 and 2020), and Kedougou (2020) regions in Senegal, were first screened for species composition by 18S ssrRNA-based nested PCR.