Publications by authors named "Serhan H"
Background: Diabetes mellitus presents significant public health challenges worldwide. While its prevalence and management in the general population have been extensively studied, comprehensive research on diabetes among incarcerated individuals is lacking. This study aims to conduct a systematic review and -analysis to determine the prevalence of diabetes within the prison population.
View Article and Find Full Text PDF: To study and evaluate the change in retinal nerve fiber layer (RNFL) and macular thickness and its clinical correlation with visual outcome following amblyopia therapy. : In this prospective interventional study, children with moderate to severe amblyopia were given optical correction and part-time occlusion therapy. Visual assessment and optical coherence tomography (OCT) were performed at days 0 and 3, 6 months of follow-up.
View Article and Find Full Text PDFObjectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.
Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.
Background And Aims: We aimed to assess the levels of hepatitis B and C knowledge, attitudes, and practices among medical students in Jordan. A survey included participation from medical students across all faculties in Jordan, from 2022 to 2023.
Methods: The data were analyzed with The R Statistical Software (v4.
Article Synopsis
- West Nile Virus (WNV) poses a significant global health risk, expanding into new regions due to climate change enhancing mosquito activity, leading to year-round virus transmission.
- Recent advancements in genomic technologies have improved understanding of WNV's behavior and potential treatment options, yet the lack of an approved vaccine means management relies heavily on supportive care for severe cases.
- There is a pressing need for innovative vector control methods and adaptive public health strategies that integrate research, policy, and community efforts to effectively combat WNV's evolving challenges.
To compare the outcomes of rAAV2-ND4 injection in treated versus fellow eyes with Leber's hereditary optic neuropathy (LHON). The protocol was pre-registered on PROSPERO (CRD42023441669). PubMed, Ovid MEDLINE, Cochrane CENTRAL, Google Scholar, Embase, CrossRef, OpenAlex, and Web of Science were reviewed from 1990-2023.
View Article and Find Full Text PDFBackground: Chronic obstructive pulmonary disease (COPD) significantly impacts global health due to persistent airflow limitation and inflammation. Despite standard therapies, symptoms persist. Ensifentrine, targeting both bronchoconstriction and inflammation as a dual phosphodiesterase 3 and 4 inhibitor, offers a promising therapeutic advancement for COPD management.
View Article and Find Full Text PDFIntroduction: Very important person (VIP) syndrome, or recommended patient syndrome (RPS), is a phenomenon in healthcare where well-intentioned efforts to enhance care inadvertently result in harm. Celebrities, physicians, and political leaders often receive preferential treatment, leading to potentially unnecessary interventions. This review delves into its causes, manifestations, consequences, real-life instances, prevention, and management, considering the shifting paradigm of recent advances in the medical field.
View Article and Find Full Text PDFPurpose: Cataract surgery is a common operation, typically carried out on older adults who have many comorbid medical conditions. Many of these patients may be undergoing aspirin therapy for diverse cardiovascular causes. Nevertheless, there is ongoing controversy regarding the administration of aspirin therapy during the perioperative period, as there are concerns regarding the risk of bleeding problems compared to thromboembolic events.
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- Myopic traction maculopathy is a significant cause of vision issues, especially in Asian populations, prompting the need to explore effective treatments like macular buckling.
- A systematic review analyzed 13 studies involving 482 eyes, evaluating the impact of macular buckling on visual acuity, axial length, and the rates of retinal reattachment and macular hole closure.
- The results indicated notable improvements in best-corrected visual acuity, consistent reductions in axial length, and high rates of retinal reattachment (94%) and macular hole closure (72%), suggesting that macular buckling is a beneficial treatment option.
Objectives: This study aims to evaluate the efficacy of Apnex, Inspire, and ImThera hypoglossal nerve stimulation (HGNS) devices in changing the severity of obstructive sleep apnea (OSA).
Method: ology: A systematic search was conducted across the databases to collect baseline and postoperative outcome measures. Articles were then filtered and data from post-filtration was extracted.
Purpose: To identify risk factors and effect modifiers associated with intraocular inflammation (IOI) following brolucizumab injection.
Methods: Our protocol was registered on PROSPERO (CRD42022382645). We searched six electronic databases (PubMed, Scopus, Web of Science, CENTRAL, EMBASE, and Google Scholar) to retrieve all studies that reported the occurrence of IOI following brolucizumab.
Background: Mpox infection is a zoonotic illness that resembles smallpox. Vaccination is widely regarded as a vital effective method of preventing mpox, however, there is lack of consensus of effectiveness of a single dose of mpox vaccine in the current 2022-2023 outbreak. We pooled data from real-world studies to evaluate the efficacy of the JYNNEOS vaccination given as a single dosage.
View Article and Find Full Text PDFPurpose: To evaluate the effectiveness and safety of trabeculectomy compared to glaucoma drainage devices (GDDs) in managing uveitic glaucoma (UG).
Design: Systematic review.
Methods: We searched seven electronic databases (PubMed, Scopus, Web of Science, ScienceDirect, EMBASE, CENTRAL, and Google Scholar) to compare trabeculectomy with various GDDs in UG.
Background: Mpox is a severe viral zoonosis that has emerged as a public health concern due to its potential for human-to-human transmission and severe illness. Understanding its clinical manifestations is crucial for effective management and control. Several systematic reviews have assessed various manifestations of Mpox.
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- Purtscher's and Purtscher-like retinopathies are rare eye conditions characterized by specific visual symptoms and potentially severe outcomes, primarily linked to trauma or systemic diseases such as systemic lupus erythematosus.
- A study analyzed 114 articles covering 168 cases, finding that trauma was the leading cause in nearly 40% of patients, and the average age of patients was around 34.6 years.
- Most patients experienced bilateral vision problems, with symptoms like blurred vision, cotton-wool spots, and Purtscher flecken being common; overall, about 53% had a favorable visual prognosis.
Article Synopsis
- The study focuses on creating patient-derived organoid (PDO) models from muscle-invasive bladder cancer tumors to better predict therapy responses and improve treatment outcomes.
- Researchers collected tumor samples from bladder cancer patients to develop these PDOs and tested them against various drugs in a lab setting, using advanced molecular profiling techniques to assess their characteristics.
- The findings showed that short-term PDOs accurately reflect the original tumors and identified potential biomarkers associated with drug responses, particularly for gemcitabine, but further validation of these results is necessary.
Background: Pedicle subtraction osteotomy (PSO) is effective for correcting spinal malalignment but is associated with high complication rates. The biomechanical effect of different PSO levels remains unclear, and no finite element (FE) analysis has compared L2-, L3-, L4-, and L5-PSOs.
Purpose: To assess the effects of PSO level on the spine's global range of motion, stresses on posterior instrumentation, load sharing with the anterior column, and proximal junctional stresses.
Purpose: Intraocular pressure (IOP) control is paramount during ophthalmic surgeries to ensure successful outcomes and prevent complications. Intravenous mannitol has been explored for its ability to manage IOP fluctuations in both vitrectomized and non-vitrectomized eyes. This meta-analysis aimed to assess the efficacy of mannitol in controlling IOP across these patient groups.
View Article and Find Full Text PDFAllvar Gullstrand, the Swedish ophthalmologist and Nobel laureate, was a self-taught mathematician who applied mathematics and higher-order equations to understand the optic system. His inventions, the slit lamp, and the ophthalmoscope are used in clinical practice for the diagnosis of eye diseases. With his efforts, he explained the accommodation, the process of changing the shape of the lens to focus on near or distant objects.
View Article and Find Full Text PDFCharles D. Kelman was a brilliant American ophthalmologist who revolutionized cataract surgery by introducing phacoemulsification to replace extracapsular cataract extraction. He used an ultrasonic probe to emulsify and aspirate the lens through a small incision (3-4 mm).
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- This text investigates the incidence and characteristics of glaucoma in patients with Vogt-Koyanagi-Harada (VKH) syndrome compared to those without glaucoma, highlighting the importance of understanding this issue for better patient care.
- The study found that the cumulative incidence of secondary glaucoma increases over time in VKH patients, with the highest rates observed in the chronic stage of VKH and in children under 18 years old.
- Although some glaucoma features in VKH patients were similar to those in non-glaucoma cases, lack of sufficient data prevented a detailed analysis of specific risk factors for glaucoma development in this group.