Publications by authors named "Serguei Simonov"

The Russian Federation is the largest and one of the most ethnically diverse countries in the world, however no centralized reference database of genetic variation exists to date. Such data are crucial for medical genetics and essential for studying population history. The Genome Russia Project aims at filling this gap by performing whole genome sequencing and analysis of peoples of the Russian Federation.

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Background: Domestic cats enjoy an extensive veterinary medical surveillance which has described nearly 250 genetic diseases analogous to human disorders. Feline infectious agents offer powerful natural models of deadly human diseases, which include feline immunodeficiency virus, feline sarcoma virus and feline leukemia virus. A rich veterinary literature of feline disease pathogenesis and the demonstration of a highly conserved ancestral mammal genome organization make the cat genome annotation a highly informative resource that facilitates multifaceted research endeavors.

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Article Synopsis
  • Tuberculosis (TB) is a global health issue, especially with rising drug-resistant strains and connections to HIV, yet there's a lack of a centralized resource linking TB genome data with geographic and clinical information.
  • The Genome-wide Mycobacterium tuberculosis Variation (GMTV) database compiles genome variations from M. tuberculosis strains in Russia, featuring data on drug resistance, clinical outcomes, and more, accessible through an online browser.
  • GMTV helps track changes in TB strains across different regions, supports research on drug resistance and clinical effects, and enhances comparisons of M. tuberculosis genomes.
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