Publications by authors named "Sergio Silva-Valenzuela"
Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial.
J Eur Acad Dermatol Venereol
September 2024
Background: Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients.
Objectives: To investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers.
Background: Maternal overweight and obesity have been associated with an increased risk of atopic dermatitis (AD) in the offspring, but the underlying mechanisms are unclear. Vernix caseosa (VC) is a proteolipid material covering the fetus produced during skin development. However, whether maternal prepregnancy weight excess influences fetal skin development is unknown.
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- The study investigated the link between obesity and atopic dermatitis (AD) in Chilean children, where obesity rates are high.
- A case-control approach was used, comparing 174 children with active AD to 101 healthy controls, assessing body mass index (BMI) and abdominal obesity.
- Results showed similar obesity rates in both groups but identified sex-specific differences in abdominal obesity: girls with AD had higher rates, while boys had lower rates compared to healthy controls.
Article Synopsis
- - Vitamin D deficiency is linked to worse atopic dermatitis (AD) in children, with unclear mechanisms on how it helps reduce symptoms.
- - In children with AD, specific immune cell characteristics showed a correlation between disease severity and levels of circulating myeloid and plasmacytoid dendritic cells (DCs).
- - Supplementing with Vitamin D was found to lower allergic markers on these immune cells, suggesting it might improve AD symptoms and highlighting the need for further research on its immunomodulatory effects.
Humoral and Cellular Autoreactivity to Epidermal Proteins in Atopic Dermatitis.
Arch Immunol Ther Exp (Warsz)
December 2016
Atopic dermatitis (AD), a chronic relapsing inflammatory disease of the skin, is an important public health concern affecting 10-20 % of children worldwide. The etiology and pathogenesis of AD involve the interplay of genetic and environmental factors, including abnormalities in skin integrity and a skewed immune system usually driven by a Th2 phenotype in childhood with a switch to Th1 in the chronic phase of disease. Children and adults with AD commonly have elevated IgE levels directed to multiple different antigens, including aeroallergens, food allergens, and microbial proteins.
View Article and Find Full Text PDFThe Scoring of Atopic Dermatitis (SCORAD) index is a widely applied instrument for measuring the severity of atopic dermatitis (AD), but few studies have evaluated the interobserver agreement between different disciplines. A cross-sectional study of 21 children with AD evaluated by dermatology and pediatric researchers found excellent agreement between the SCORAD, the objective SCORAD, and the Three Item Severity score, confirming the applicability of these scores by nondermatologists.
View Article and Find Full Text PDF[Combined norms for the prevention of vertical transmission of HIV and syphillis infection].
Rev Chilena Infectol
June 2013