Many classification problems, especially in the field of bioinformatics, are associated with more than one class, known as multi-label classification problems. In this study, we propose a new adaptation for the Binary Relevance algorithm taking into account possible relations among labels, focusing on the interpretability of the model, not only on its performance. Experiments were conducted to compare the performance of our approach against others commonly found in the literature and applied to functional genomic datasets.
View Article and Find Full Text PDFAnalysis of bacterial diversity in soils along the banks of the Solimões and Negro rivers, state of Amazonas, Brazil, was by partial sequencing of the genes codifying the rDNA16S region. Diversity of operational taxonomic units (OTU) and of the divergent sequences obtained were applied in comparative analysis of microbiological diversity in the two environments, based on richness estimators and OTU diversity indices. The higher OTU diversity in the Solimões was based on the higher number of parameters that evoke this.
View Article and Find Full Text PDFAdaptation or acclimation to hypoxia occurs via the modulation of physiologically relevant genes, such as erythropoietin, transferrin, vascular endothelial growth factor, phosphofructokinase and lactate dehydrogenase A. In the present study, we have cloned, sequenced and examined the modulation of the LDH-A gene after an Amazonian fish species, Astronotus crassipinis (the Oscar), was exposed to hypoxia and anoxia. In earlier studies, we have discovered that adults of this species are extremely tolerant to hypoxia and anoxia, while the juveniles are less tolerant.
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