Bioguided Identification of Active Antimicrobial Compounds from and Root Tubers.

Root tubers of subsp. (AbR), a vulnerable endemic species, and subsp. (AmR) have traditionally been used in Portugal to treat inflammatory and infectious skin disorders.

Identification of Marker Compounds and In Vitro Toxicity Evaluation of Two Portuguese Leaf Extracts.

The leaves of subsp. , an endemic Portuguese species, and subsp. have been used as food, and traditionally as medicine, for treating ulcers, urinary tract, and inflammatory disorders.

Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling.

Introduction: The development of reliable hepatic models may provide insights into disease mechanisms, linking hepatocyte dysmetabolism and related pathologies. However, several of the existing models depend on using high concentrations of hepatocyte differentiation-promoting compounds, namely glucose, insulin, and dexamethasone, which is among the reasons that have hampered their use for modeling metabolism-related diseases. This work focused on modulating glucose homeostasis and glucocorticoid concentration to improve the suitability of a mesenchymal stem-cell (MSC)-derived hepatocyte-like cell (HLC) human model for studying hepatic insulin action and disease modeling.

Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells.

Aquaporins (AQPs) facilitate water and glycerol movement across membranes. AQP7 is the main aquaglyceroporin in pancreatic β-cells and was proposed to play a role in insulin exocytosis. Although AQP7-null mice display adult-onset obesity, impaired insulin secretion and insulin resistance, AQP7 loss-of-function homozygous mutations in humans do not correlate with obesity nor type-2 diabetes.