Publications by authors named "Sergio Pandolfi"
Article Synopsis
- Cardiovascular diseases (CVDs) are a serious global health issue, prompting extensive research focused on prevention through lifestyle changes, diet, and improved medical knowledge.
- Ozone therapy is gaining attention as it stimulates the endothelial nitric oxide synthase/nitric oxide pathway, potentially offering new treatment options to mitigate endothelial and cardiac problems related to CVDs, such as atrial fibrillation.
- This review aims to outline effective methods for using ozone in treating cardiovascular issues, particularly acute myocardial infarction from ischemic conditions, and emphasizes the need for further research in this area.
Article Synopsis
- - Knee osteoarthritis (OA) is a chronic condition that causes pain, stiffness, and difficulty moving the knee joint, and current treatments like platelet-rich plasma and hyaluronic acid have shown limited effects on managing symptoms.
- - A recent study explored the effectiveness of ozonated blood infusions for treating knee OA, finding that 250 patients showed approximately a 50% improvement in their health status after only five treatment sessions.
- - The ozone therapy significantly reduced pain, disability, and stiffness, with positive outcomes reflected through WOMAC and Lequesne functional indexes for both men and women with varying severity of knee OA.
Article Synopsis
- * Two clinical studies demonstrated the effectiveness of ozone in treating infected post-surgical wounds and knee osteoarthritis, with notable reductions in infection and inflammation.
- * The findings suggest that ozone therapy can enhance immune response, promote bacterial clearance, and alleviate symptoms in patients with specific conditions.
Article Synopsis
- * It operates on the principle of hormesis at low doses, promoting cell protection through the activation of the body's antioxidant systems and having anti-inflammatory effects.
- * As a bioregulator, ozone enhances mitochondrial function and influences complex regulatory mechanisms in cells, making it a novel approach in pharmacology and medical treatments.
Article Synopsis
- - Ozone, a form of oxygen, is being researched for its potential to help treat bacterial infections in wounds, especially those caused by drug-resistant bacteria.
- - It works by activating a protein called Nrf2, which initiates a series of biological responses that enhance the function of immune cells known as macrophages in clearing infections.
- - This review focuses on the latest findings regarding how ozone influences immune responses and its effectiveness against both regular and multidrug-resistant bacteria.
A comment to: Ghaleh HEG, Izadi M, Javanbakht M, Ghanei M, Einollahi B, Jafari NJ, Alishiri G, Aslani J, Abolghasemi H, Simonetti V, Khafaei M, Zhao S, Saadat SH, Ahmadi M, Parvin S, Vazifedoust S, Alvanagh AG. Cytokine profile and antioxidants status in the moderate and severe COVID-19 patients: a trial of ozone therapy impact as a medicinal supplement. Inflammopharmacology.
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- COVID-19 emerged in late 2019, with Italy being one of the first Western countries hit hard, facing a lack of knowledge and treatment guidelines initially.
- The Italian Health Ministry suggested that treatment was only necessary if oxygen levels dropped below 92%, leading to delays in care that contributed to increased hospitalizations and a high death rate of 3.5%.
- Volunteer groups swiftly began treating patients at home using non-steroidal anti-inflammatory drugs and repurposed medications, achieving better outcomes and fewer hospitalizations, highlighting the need for collaboration between healthcare institutions and community physicians for effective treatment strategies.
Article Synopsis
- * The therapy combats oxidative stress and chronic inflammation, both of which contribute to the severity of COVID-19 and its long-term effects.
- * The review aims to explain how medical ozone works at a molecular level, evaluate its clinical effectiveness for COVID-19, and explore its potential to alleviate post-COVID-related health issues.
COVID-19 Medical and Pharmacological Management in the European Countries Compared to Italy: An Overview.
Int J Environ Res Public Health
April 2022
Article Synopsis
- - Italy has the highest COVID-19 death toll in Europe, with over 150,000 deaths, prompting a comparison of its emergency management to that of other European countries.
- - The study utilized literature reviews and mathematical algorithms to analyze various pandemic management strategies across Europe, revealing Italy's poor ranking in effective COVID-19 response.
- - Key factors contributing to Italy's high mortality rate include its aging population, a decentralized healthcare system, and inefficiencies in early treatment and home care strategies for COVID-19 patients.
Article Synopsis
- * A study involving 200 ME/CFS patients assessed the effectiveness of oxygen-ozone autohemotherapy (O-O-AHT) on fatigue reduction, using a scoring questionnaire before and after a month of treatment.
- * Results showed that female patients experienced significantly better improvements in fatigue compared to male patients, especially in the 14-29 age group, indicating a gender difference in treatment response.
Article Synopsis
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a condition marked by extreme fatigue, and ozone therapy has shown promise in relieving this symptom.
- In a study involving 200 diagnosed ME/CFS patients (average age 33), oxygen-ozone autohemotherapy (O-O-AHT) was administered, and fatigue levels were assessed before and 30 days after treatment using a questionnaire.
- Results indicated that 43.5% of patients improved significantly in fatigue scores, with 77.5% reporting notable reductions in fatigue; no side effects were noted, and benefits lasted for at least three months post-treatment.
Article Synopsis
- A study analyzed the medical records of 158 Italian patients with early COVID-19 treated at home, focusing on prescribed versus non-prescribed treatments.
- Patients were divided into two groups based on how quickly they received treatment after symptom onset, with those treated within 72 hours experiencing better outcomes.
- Findings showed that earlier treatment significantly shortened symptom duration and eliminated hospitalizations in the early treatment group, highlighting the importance of timely medical intervention.