Publications by authors named "Sergio Leotta"
Article Synopsis
- This study investigates whether adding pioglitazone or sulfonylureas to metformin improves cardiovascular outcomes in patients with type 2 diabetes who don't achieve good control with metformin alone.
- Conducted as a multicenter trial in Italy, it involved 3028 patients aged 50-75 over a median follow-up of about 57 months.
- The trial was halted early due to futility, with only 105 patients experiencing the primary cardiovascular outcome during the study period.
No randomized clinical trials (RCTs) have yet evaluated the bariatric surgery's efficacy and safety in patients newly diagnosed with type 2 diabetes mellitus (T2DM). The aim of this multicenter RCT is to compare bariatric surgery, particularly laparoscopic sleeve gastrectomy (LSG), with conventional medical therapy (CMT) in obese patients (body mass index between 30 and 42 kg/m) newly diagnosed with T2DM and without any diabetes-related complications at any stage. A total of 100 eligible patients will be randomized at a 1:1 ratio to undergo one of the two planned treatments and will be followed for at least 6 years after randomization.
View Article and Find Full Text PDFInsulin therapy is still the gold standard in diabetic pregnancy. Insulin lispro protamine suspension is an available basal insulin analogue. Aim.
View Article and Find Full Text PDFBackground: We compared telecare and conventional self-monitored blood glucose (SMBG) programs for titrating the addition of one bolus injection of insulin glulisine in patients with type 2 diabetes uncontrolled on oral hypoglycemic agents for ≥3 months who were first titrated with basal insulin glargine.
Methods: This randomized, multicenter, parallel-group study included 241 patients (mean screening glycosylated hemoglobin [HbA(1c)], 8.8% [73 mmol/mol]).
Background: In Italy many diabetics still lack adequate care in general practice. We assessed the effectiveness of different strategies for the implementation of an evidence-based guideline for the management of non-complicated type 2 diabetes among General Practitioners (GPs) of Lazio region.
Methods: Three-arm cluster-randomised controlled trial with GPs as units of randomisation (clusters).