Publications by authors named "Sergio L Angulo"
Introduction: Alzheimer's disease (AD) is linked to neuronal calcium dyshomeostasis, which is associated with network hyperexcitability. Decreased expression of the calcium-binding protein cal- bindin-D (CB) might be a susceptibility factor for AD. The subiculum is affected early in AD, for unknown reasons.
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- * Researchers found that brains of mice with APOE4 showed increased neuron activity, especially in a brain area called the entorhinal cortex.
- * This increased brain activity might happen because the normal calming signals from certain neurons (like GABA) aren't working well, which could explain why people with APOE4 have a higher risk of Alzheimer's.
In this review, we discuss the genetic etiologies of Alzheimer's disease (AD). Furthermore, we review genetic links to protein signaling pathways as novel pharmacological targets to treat AD. Moreover, we also discuss the clumps of AD-m ediated genes according to their single nucleotide polymorphism mutations.
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