[Epigenetics and epigenome. A step forward in the etiology and potential treatment of neurological diseases].

The mechanisms of epigenetic regulation play an important role in the development and function of body systems. Failure in the maintenance of this regulation as well as environmental factors could contribute to the development of multiple diseases in genetically predisposed patients. Although the molecular mechanisms responsible for the etiology of most diseases are unknown, there is evidence of both genetic and environmental factors that could influence this development.

[Role of T-regulatory cells in multiple sclerosis].

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions.

Hair shaft abnormalities. Pili bifurcati: a scanning electron microscopy analysis.

Pili bifurcati is an extremely rare hair shaft abnormality. We present a case with a scanning electron microscopy analysis.