Peripartum Hysterectomies over a Fifteen-year Period.

Objective:  To determine the indications and outcomes of peripartum hysterectomies performed at Hospital de Clínicas de Porto Alegre (a university hospital in Southern Brazil) during the past 15 years, and to analyze the clinical characteristics of the women submitted to this procedure.

Methods:  A cross-sectional study of 47 peripartum hysterectomies from 2005 to 2019.

Results:  The peripartum hysterectomies performed in our hospital were indicated mainly due to placenta accreta or suspicion thereof (44.

Preeclampsia.

The authors review hypertensive disease during pregnancy with an academic and practical view, and using the best evidence available. This disease, which is the most important clinical disease in Brazilian pregnant women, may have its incidence reduced with prevention through the use of calcium and aspirin in pregnant women at risk. Previously, it was a disease that presented with but it has now been classified with new clinical parameters besides proteinuria.

Comparison of serum selenium levels among hypertensive and normotensive pregnant women.

Objective: To correlate serum selenium levels with hypertensive disorders of pregnancy (HDP) in a selected population and evaluate this mineral as a possible protective factor.

Methods: This case-control study included 32 normotensive, 20 hypertensive (chronic and gestational hypertension), and 38 preeclamptic pregnant women. All patients were recruited from antenatal or obstetric admissions of a tertiary hospital in Brazil.

Insulin stimulation of Akt/PKB phosphorylation in the placenta of preeclampsia patients.

Context And Objective: Preeclampsia is a multi-systemic disease and one of the most frequent severe health problems during pregnancy. Binding of insulin triggers phosphorylation and activates cytoplasmic substrates such as phosphatidylinositol 3 kinase (PI3K). Phosphorylation of membrane phosphoinositide 2 (PIP2) to phosphoinositide 3 (PIP3) by PI3K starts Akt/PKB activation.

Calcium-to-creatinine ratio in pregnancy-induced hypertension.

Objectives: Hypocalciuria has been correlated with preeclampsia. This study compared the calcium-to-creatinine ratio among the groups, and the correlation with the 24-h measurement of this ratio and a diagnosis of preeclampsia.

Study Design: Case-control study including mild and severe preeclampsia, chronic hypertension and normal pregnancy.

Protein creatinine ratio in random urine sample of hypertensive pregnant women: maternal and perinatal outcomes.

Objective. To compare protein/creatinine ratio (PCR) in random urine sample levels and adverse outcomes in hypertensive pregnant women. Methods.

Are insulin resistance index, IGF-1 and metabolic syndrome components correlates with severe preeclampsia?

Objective: Analyse the relation between insulin resistance and severe preeclampsia (SPE).

Methods: Case control study paired by body mass index and gestational age; including 16 patients with severe SPE and 16 normotensive controls. Insulin resistance was assessed through the HOMA-IR and QUICKI-IS indexes.

Risk factors for cardiovascular disease ten years after preeclampsia.

Context And Objective: Preeclampsia is a gestational disease that occurs mainly among nulliparous women after the 20th week of gestation, and frequently close to delivery. The effects of preeclampsia on women's blood pressure over the long term are still controversial. Patients with recurrent preeclampsia or preeclampsia in the early stages of pregnancy appear to present higher risk of hypertension.

Signalization of Akt/PKB in the placenta, skeletal muscle and adipose tissue of preeclampsia patients.

Unlabelled: Preeclampsia (PE) is a significant cause of fetal and maternal mortality around the world and there is evidence that insulin resistance has been implicated in the pathophysiology of PE. The Akt/PKB pathway is stimulated by insulin and performs several vital functions relative to growth, survival and cellular metabolism.

Objective: To investigate the basal expression of Akt/PKB, HSP90 expression, proteins that regulate Akt/PKB activity and substrate in the placenta, skeletal muscle and adipocytes of normal and PE parturient.