Publications by authors named "Sergio Guber"
Article Synopsis
- Cells from the bone marrow play a vital role in repairing blood vessel linings, but cardiovascular diseases can reduce their numbers and effectiveness.
- Gene transfer of endothelial nitric oxide synthase (eNOS) can enhance the activity of these cells, and estrogen boosts their healing capacity.
- Overexpressing eNOS or stimulating early outgrowth cells (EOCs) with estrogen significantly increases their survival and ability to limit the movement of smooth muscle cells, helping to prevent issues related to vascular remodeling.
Glucocorticoids play an important role in adipogenesis through the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high molecular weight immunophilin, either FKBP51 or FKBP52. When 3T3-L1 preadipocytes are induced to differentiate, FKBP51 expression progressively increases, whereas FKBP52 decreases, and Hsp90, Hsp70, p23 and Cyp40 remain unchanged. Interestingly, FKBP51 rapidly translocates from mitochondria to the nucleus where it is retained upon its interaction with chromatin and the nuclear matrix.
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