The Multi-temporal and Multi-dimensional Global Urban Centre Database to Delineate and Analyse World Cities.

Monitoring sustainable urban development requires comparable geospatial information on cities across several thematic domains. Here we present the first global database combining such information with city extents. The Global Human Settlement Urban Centre Database (GHS-UCDB) is produced by geospatial data integration to characterise more than 10,000 urban centres worldwide.

Estimating geographic access to healthcare facilities in Sub-Saharan Africa by Degree of Urbanisation.

Measuring rates of coverage and spatial access to healthcare services is essential to inform policies for development. These rates tend to reflect the urban-rural divide, typically with urban areas experiencing higher accessibility than rural ones. Especially in Sub-Saharan Africa (SSA), a region experiencing high disease burden amid fast urbanisation and population growth.

A smart and flexible approach for aggregation of adjacent polygons to meet a minimum target area or attribute value.

Many geospatial analyses require flexible aggregation of adjacent units to meet a minimum target area or attribute value. This is usually accomplished using several non-automated and complex GIS tasks. We developed an integrated user-friendly approach and algorithm implemented in the 'GHS-SmartDissolve' tool, which addresses minimum mapping unit or attribute value requirements, layers resolution mismatch, spatial uncertainty or modifiable areal unit problem in GIScience.

Low phase angle in critically ill older patients is associated with late mortality: A prospective study.

Objectives: The aim of this study was to ascertain the accuracy of phase angle (PhA) as a predictor of mortality during intensive care unit (ICU) stay (M) and at 28 (M) and 60 d (M) after ICU admission among patients aged >60 y.

Methods: Patients aged >60 y who were under mechanical ventilation (MV) ≥48 h were included once they were hemodynamically stable. PhA was measured by single-frequency bioelectrical impedance analysis up to 48 h after admission.

Land use efficiency of functional urban areas: Global pattern and evolution of development trajectories.

The application of last-generation spatial data modelling, integrating Earth Observation, population, economic and other spatially explicit data, enables insights into the sustainability of the global urbanisation processes with unprecedented detail, consistency, and international comparability. In this study, the land use efficiency indicator, as developed in the Sustainable Development Goals, is assessed globally for the first time at the level of Functional Urban Areas (FUAs). Each FUA includes the city and its commuting zone as inferred from statistical modelling of available spatial data.

Built-up areas within and around protected areas: Global patterns and 40-year trends.

Protected areas (PAs) are a key strategy in global efforts to conserve biodiversity and ecosystem services that are critical for human well-being. Most PAs have some built-up structures within their boundaries or in surrounding areas, ranging from individual buildings to villages, towns and cities. These structures, and the associated human activities, can exert direct and indirect pressures on PAs.

Evaluation of Inertial Sensor Data by a Comparison with Optical Motion Capture Data of Guitar Strumming Gestures.

Computing technologies have opened up a myriad of possibilities for expanding the sonic capabilities of acoustic musical instruments. Musicians nowadays employ a variety of rather inexpensive, wireless sensor-based systems to obtain refined control of interactive musical performances in actual musical situations like live music concerts. It is essential though to clearly understand the capabilities and limitations of such acquisition systems and their potential influence on high-level control of musical processes.

Uncovering temporal changes in Europe's population density patterns using a data fusion approach.

The knowledge of the spatial and temporal distribution of human population is vital for the study of cities, disaster risk management or planning of infrastructure. However, information on the distribution of population is often based on place-of-residence statistics from official sources, thus ignoring the changing population densities resulting from human mobility. Existing assessments of spatio-temporal population are limited in their detail and geographical coverage, and the promising mobile-phone records are hindered by issues concerning availability and consistency.

Querying Archetype-Based Electronic Health Records Using Hadoop and Dewey Encoding of openEHR Models.

Archetype-based Electronic Health Record (EHR) systems using generic reference models from e.g. openEHR, ISO 13606 or CIMI should be easy to update and reconfigure with new types (or versions) of data models or entries, ideally with very limited programming or manual database tweaking.

Comparing the Performance of NoSQL Approaches for Managing Archetype-Based Electronic Health Record Data.

This study provides an experimental performance evaluation on population-based queries of NoSQL databases storing archetype-based Electronic Health Record (EHR) data. There are few published studies regarding the performance of persistence mechanisms for systems that use multilevel modelling approaches, especially when the focus is on population-based queries. A healthcare dataset with 4.

Taking advantage of reduced droplet-surface interaction to optimize transport of bioanalytes in digital microfluidics.

Digital microfluidics (DMF), a technique for manipulation of droplets, is a promising alternative for the development of "lab-on-a-chip" platforms. Often, droplet motion relies on the wetting of a surface, directly associated with the application of an electric field; surface interactions, however, make motion dependent on droplet contents, limiting the breadth of applications of the technique. Some alternatives have been presented to minimize this dependence.

Name segmentation using hidden Markov models and its application in record linkage.

This study aimed to evaluate the use of hidden Markov models (HMM) for the segmentation of person names and its influence on record linkage. A HMM was applied to the segmentation of patient's and mother's names in the databases of the Mortality Information System (SIM), Information Subsystem for High Complexity Procedures (APAC), and Hospital Information System (AIH). A sample of 200 patients from each database was segmented via HMM, and the results were compared to those from segmentation by the authors.

Additive-free digital microfluidics.

Digital microfluidics, a technique for manipulation of droplets, is becoming increasingly important for the development of miniaturized platforms for laboratory processes. Despite the enthusiasm, droplet motion is frequently hindered by the desorption of proteins or other analytes to surfaces. Current approaches to minimize this unwanted surface fouling involve the addition of extra species to the droplet or its surroundings, which might be problematic depending on the droplet content.

A record linkage process of a cervical cancer screening database.

This paper aims at to present the integration of the files of the Brazilian Cervical Cancer Information System (SISCOLO) in order to identify all women in the system. SISCOLO has the exam as the unit of observation and the women are not uniquely identified. It has two main tables: histology and cytology, containing the histological and cytological examinations of women, respectively.

Modeling healthcare authorization and claim submissions using the openEHR dual-model approach.

Background: The TISS standard is a set of mandatory forms and electronic messages for healthcare authorization and claim submissions among healthcare plans and providers in Brazil. It is not based on formal models as the new generation of health informatics standards suggests. The objective of this paper is to model the TISS in terms of the openEHR archetype-based approach and integrate it into a patient-centered EHR architecture.

[An information system to integrate outpatient cancer care data in the Unified National Health System].

This study focuses on the development of a system to integrate monthly outpatient cancer care data in the Unified National Health System (SUS). The system was modeled to retrace the treatment evolution in each cancer case and services output, with the following advantage: the system focuses on the cancer case, does not require knowledge by the user in order to handle the database, and allows updating the base as new data emerge. The results of direct queries in the system were identical to those obtained from direct inspection of the original database and those from another integration approach.

Digital microfluidics for automated proteomic processing.

Clinical proteomics has emerged as an important new discipline, promising the discovery of biomarkers that will be useful for early diagnosis and prognosis of disease. While clinical proteomic methods vary widely, a common characteristic is the need for (i) extraction of proteins from extremely heterogeneous fluids (i.e.

All-terrain droplet actuation.

Digital microfluidics has become a popular tool for biochemical and biomedical applications. However, its current format is restricted to actuation of droplets on a single plane. Here, we introduce a new method for fluid handling on flexible devices, which we have termed all-terrain droplet actuation (ATDA).

A practical interface for microfluidics and nanoelectrospray mass spectrometry.

We report a new method for fabricating nanospray ionization tips for MS, formed from glass substrates and the inert polymer, parylene-C. Using a single photolithography step, the emitters are formed contiguously with microchannels, such that no dead volumes are observed. In addition, because the devices are very thin (approximately 0.

[Relation between the resistance index obtained by the transfontanellar Doppler ultrasonography and the neurological development until the first year of life in term infants with mild or moderate hypoxic-ischaemic encephalopathy].

Objective: To evaluate the relation between the resistance index (RI) obtained by transfontanellar Doppler ultrasonography, and the neurodevelopment until one year of life, at term newborns with mild or moderate hypoxic-ischaemic encephalopathy due to intrapartum asphyxia.

Method: 20 term newborns, with mild or moderate hypoxic-ischemic encephalopathy, high values of resistance index in the first exam, and without cerebral morfologic abnormalities or other diseases. They were submitted to serial bimonthly transfontanellar Doppler ultrasonography, from the seventh day of life on, and monthly clinical neurodevelopment assessment until one year of life.

Proteome-on-a-chip: mirage, or on the horizon?

Proteomics has emerged as the next great scientific challenge in the post-genome era. But even the most basic form of proteomics, proteome profiling, i.e.