IgM plasma cell myeloma with amyloidosis presenting as mammary microcalcifications.

We report the case of an otherwise healthy 67-year-old woman who presented with bilateral breast masses and calcifications. Bilateral mammary biopsies showed infiltration by monoclonal neoplastic plasma cells and diffuse osseous metaplasia. Congo red stains and immunohistochemistry showed amyloid deposits.

Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.

Tubular carcinoma (TC) is a distinctive type of grade I (G1) ductal carcinoma with particularly favourable outcome and low rate of axillary metastases. To the best of our knowledge, few data are available in the literature concerning the expression of molecules mediating intercellular and cell-matrix interactions in TC. We examined with immunohistochemical methods the expression of galectin 3 and cathepsin D in 17 TC and in 33, 31 and 28 ductal carcinomas of G1, grade II (G2) and grade III (G3), respectively.

[Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report].

Breast tumors, particularly of stromal origin, containing multinucleated osteoclast-like giant cells (OLGC) are rarely reported in the literature. We report here the first case of a malignant phyllodes tumor associated with OLGC occurring in a 43 year-old African woman who presented with a painful palpable mass of the outer upper quadrant of the right breast. After surgical excision, histological examination showed a malignant phyllodes tumor in which the stromal component displayed evident sarcomatous changes and was densely populated with benign multinucleated OLGC.

Proliferating activity in columnar cell lesions of the breast.

With the introduction of mammographic screening, columnar cell lesions (CCLs) are observed more and more frequently because they are often associated with microcalcifications. Until now, the proliferative activity of these lesions has not been previously evaluated. Ki67 index was performed by immunohistochemistry in CCLs without atypia [columnar cell change (CCC) n = 20 and columnar cell hyperplasia without atypia (CCH without atypia) n = 20], flat epithelial atypia (FEA DIN1A n = 20), low-grade intraductal carcinoma (DIN1C n = 20), high-grade intraductal carcinoma (DIN 2-3 n = 20).

Microvessel and lymphatic density in tubular carcinoma of the breast: comparative study with invasive low-grade ductal carcinoma.

Tubular carcinoma (TC) of the breast is an uncommon variant of ductal carcinoma, which has an extremely low metastatic potential and an excellent prognosis. Studies concerning the vascular and lymph vessel status in TC are not numerous and hampered by a lack of specific markers. We immunohistochemically analysed the expression of CD31 and D2-40 antibodies in 15 TC measuring less than 2cm in diameter.

[Placental lesions in human Trypanosoma cruzi infection].

This histopathological study analyzes placentas of babies congenitally infected with T. cruzi (M+B+), or babies not infected but born from infected- (M+B-), or non infected-mothers (M-B-). Placentas M+B+ showed lesions of chorionitis, chorioamnionitis and cord edema with lymphocyte infiltration, whereas such lesions were infiltrated only with polymorphonuclear cells in M+B- and M-B- placentas.

Tubular carcinoma of the breast and associated intra-epithelial lesions: a comparative study with invasive low-grade ductal carcinomas.

Ductal intra-epithelial lesions of the breast are associated with invasive neoplasms and comprise a large spectrum of histological patterns. We have examined 23 cases of pure tubular carcinomas (TCs) of the breast and 53 cases of invasive ductal low-grade carcinomas to determine the relationship and distribution of intra-epithelial lesions, mainly of ductal in situ carcinoma type, but including also lobular intra-epithelial neoplasia (LIN) in both entities. Eleven cases of TC showed flat epithelial atypia (FEA) (47.

Is complete axillary lymph node dissection neccessary in T1 stage invasive pure tubular carcinomas of the breast?

The purpose of this study was to evaluate the frequency of axillary lymph node metastasis in invasive pure (not mixed) tubular carcinomas of the breast and to compare our results to other series published in the literature. We analyzed 16 cases of pure tubular carcinoma measuring 2 cm or less in diameter from our database from 1988 to 2004 diagnosed in lumpectomy and mastectomy specimens with associated axillary lymph node dissection. Histopathologic features were reviewed in all patients.

[P63 protein in the diagnosis of breast tubular carcinoma].

Aims: To study and compare the expression of p63 protein and smooth muscle actin in breast tubular carcinoma (TC) and its main differential diagnoses, radial scar (RS)/complex sclerosing lesion (CSL).

Materials And Methods: Immunohistochemistry techniques were used to search for p63 protein and smooth muscle actin antibodies in 10 patients with TC and fifteen with RS/CSL.

Results: Myoepythelial cells were diffusely positive for both actin and p63 protein with a cytoplasmic (actin) or nuclear (p63) pattern in all patients with RS/CSL.

Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis.

Hamartoma is a rare, non-neoplastic tumor characterized by an abnormal mixture of tissues, which are indigenous to the region. They are rare in the nasal cavity. We report a 79-year-old woman with an adenomatoid hamartoma in the left nasal cavity associated with nasal polyposis.

Benign phyllodes tumor associated with Maffucci's syndrome.

Reports of breast tumors together with Maffucci's syndrome are extremely rare in the literature. Maffucci's syndrome is an uncommon congenital disease characterized by the association of multiple enchondromas and different types of hemangiomas. To the best of our knowledge, this is the first well-documented case of a benign phyllodes tumor of the breast occurring in a patient with Maffucci's syndrome.

Spindle cell vulvar hemangiomatosis associated with enchondromatosis: a rare variant of Maffucci's syndrome.

Spindle cell hemangioma is a rare vascular tumor that most frequently involves the distal extremities, especially the hand. We report a case of spindle cell hemangiomatosis of the vulva in an 18-year-old woman with Maffucci's syndrome, the first report of such a case, to the best of our knowledge. The vascular lesions, present from the age of 2, were located in the right olecranon, the third left toe, and the vulva.

Neuroma of the clitoris after female genital cutting.

Background: Nerve tumors of the clitoris and particularly neuromas are extremely rare.

Case: A 27-year-old infibulated African woman suffering from chronic vulvar pain increasing with sexual intercourse presented for gynecologic care. Examination revealed a painful clitoral tumor.