Proliferation of the superficial epithelium of ovaries in senile female rats following oral administration of conjugated equine estrogens.

Objective: To evaluate the effect of different concentrations of estrogen on the ovarian superficial epithelium in senile female rats.

Design: Fifty female rats at 15 months of age and with irregular estrous cycles were selected and randomly divided into five experimental groups containing equal numbers of animals in each: GPROP, control group receiving vehicle only; GE0.05mg, group receiving conjugated equine estrogens (CEE) at a dose of 50 microg/kg; GE0.