Bioinformatics-based Characterization of the Sequence Variability of Zika Virus Polyprotein and Envelope Protein (E).

Background: Zika virus, which is widely spread and infects humans through the bites of and female mosquitoes, represents a serious global health issue.

Objective: The objective of the present study is to computationally characterize Zika virus polyproteins (UniProt Name: PRO_0000443018 [residues 1-3423], PRO_0000445659 [residues 1-3423] and PRO_0000435828 [residues 1-3419]) and their envelope proteins using their physico-chemical properties.

Methods: To achieve this, the Polarity Index Method (PIM) profile and the Protein Intrinsic Disorder Predisposition (PIDP) profile of 3 main groups of proteins were evaluated: structural proteins extracted from specific Databases, Zika virus polyproteins, and their envelope proteins (E) extracted from UniProt Database.

Surface coil with reduced specific absorption rate for rat MRI at 7 T.

Objective: A scaled-down slotted surface radio frequency (RF) coil was built, and the specific absorbance rate (SAR) in 100 mg of tissue (SAR100 mg) produced in a rat brain phantom was computed at 7 T.

Materials And Methods: A slotted coil 2-cm in diameter with six circular slots was developed. Its theoretical and experimental performance was computed and compared using the signal-to-noise ratio (SNR) expression and phantom images obtained with a spin echo sequence.