Publications by authors named "Sergio Dortas Junior"
Article Synopsis
- Acquired deficiency of C1 inhibitor (AAE-C1-INH) is a rare cause of recurrent angioedema, with this study focusing on cases from Brazilian reference centers to better understand its characteristics.
- A total of 14 patients were analyzed, mostly female, with an average symptom onset age of 56.5 years, and a median diagnostic delay of 2 years; the primary symptoms were skin-related.
- Most patients had abnormal levels of C4 and C1-INH, and many needed long-term treatment; ultimately, 85.7% found resolution of their angioedema issues with appropriate therapy.
Article Synopsis
- - This study aimed to investigate the effects of SARS-CoV-2 infection on Brazilian patients with Inborn Errors of Immunity (IEI), focusing on their clinical outcomes and factors influencing the infection.
- - In a multicenter study of 121 patients, the majority experienced mild or asymptomatic cases, with serious outcomes primarily linked to older age and specific comorbidities (like bronchiectasis and cardiopathy) rather than the type of IEI itself.
- - Despite most infections being mild, the case fatality rate for these patients was higher than the general population, highlighting the need for targeted care in individuals with IEI.
The urticaria control test (UCT) is a patient-reported outcome measure designed to determine the current level of disease control in patients with chronic urticaria (CU). Recently, a Brazilian UCT was developed, but its validity and reliability are unknown. The clinimetric properties of the Brazilian UCT short form (UCTsh) and its long form (UCTlg) were determined in 130 patients with CU.
View Article and Find Full Text PDFThe European Respiratory Society (ERS) International Congress 2019 in Madrid, Spain, was a platform for scientific discussion of the highest quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory field. This article discusses some of the high-quality research studies presented at that Congress, with a focus on airway diseases, including asthma, COPD, small airways, bronchiectasis and cough, presented through the Airway Diseases, Asthma and COPD Assembly (Assembly 5) of the ERS. The authors establish the key take-home messages of these studies, compare their findings and place them into context of current understanding.
View Article and Find Full Text PDFBackground: Atopic Dermatitis is a chronic inflammatory skin disease. Food allergens are important in the pathogenesis in 1/3 of the cases. Several mechanisms are involved in the pathogenesis of Atopic Dermatitis.
View Article and Find Full Text PDFArticle Synopsis
- Hereditary Angioedema is a genetic condition inherited in a dominant manner, but routine testing for autoantibodies (AAB) in these patients is not standard practice.
- A study involving 15 patients with Hereditary Angioedema at a university hospital found that 40% had AAB, indicating a notable prevalence.
- The findings suggest a high rate of AAB among affected individuals, emphasizing the need for larger studies to evaluate the impact of these antibodies on patient care.