Publications by authors named "Sergio Buenaventura-Cisneros"
Article Synopsis
- Melanoma treatment has significantly advanced with checkpoint blockade immunotherapy (CBI), focusing on understanding immune cell interactions within tumors for better responses to therapy.
- The study utilized advanced techniques to analyze two cohorts of melanoma patients—one without treatment and another receiving immunotherapy—highlighting the role of tissue-resident memory (TRM) CD8 T cells and dendritic cells in cancer immunity.
- Findings revealed two distinct TRM CD8 T cell subsets (TCF1+ and TCF1-) that exhibit different protein expressions linked to melanoma protection, with their spatial distribution in tumors being crucial for understanding their impact on treatment outcomes.
Background: The diagnosis and treatment of colorectal cancer are considered highly stressful and potentially traumatic events that can generate post-traumatic stress symptoms and distress among patients.
Objective: This study assessed levels of post-traumatic stress symptoms, distress, and optimism, as well as differences between these conditions relative to sociodemographic and medical variables, in Mexican patients with colorectal cancer.
Design: A cross-sectional descriptive study design was employed, in which 192 colorectal cancer patients over the age of 18 years participated.
In this study, we evaluated the influence of sex, age, clinical stage, and colostomy/ileostomy variables on the quality of life of Mexican patients with colorectal cancer. Using a descriptive cross-sectional design, 192 colorectal cancer patients were included in the study. Significant differences were observed in emotional functioning between patients with rectal cancer and those with colon cancer.
View Article and Find Full Text PDFObjective: Determine the feasibility and the preliminary effects of brief cognitive behavioral stress management (CBSM) intervention, compared with psychoeducation (PE) group in posttraumatic stress, distress, optimism, and quality of life in patients with colorectal cancer.
Methods: Ninety-four patients were randomized: 40 in CBSM intervention and 54 in PE. They answered psychological questionnaires before and after the intervention and 3 months later for follow-up.
Thymidylate synthase gene variants as predictors of clinical response and toxicity to fluoropyrimidine-based chemotherapy for colorectal cancer.
Drug Metab Pers Ther
December 2017
Background: Fluoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments and even suspension of the treatment. The thymidylate synthase (TYMS) gene is a potential marker of response and toxicity to fluoropyirimidines as this enzyme is the molecular target of these drugs.
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