5-fluorouracil-based chemoradiation in unresectable pancreatic carcinoma: Phase I-II dose-escalation study.

Purpose: A Phase I-II dose-escalation study was performed to evaluate the possible impact of the dose on response, toxicity, pain relief, and outcome in patients with unresectable pancreatic carcinoma.

Methods And Materials: A total of 50 patients entered the study. The external beam radiotherapy (RT) dose was 39.

Pain relief with short-term irradiation in locally advanced carcinoma of the pancreas.

Objectives: To evaluate whether a short radiation treatment (30 Gy, 3.0 Gy/fraction) had analgesic efficacy in patients with unresectable pancreatic carcinoma.

Methods: Twelve patients were included in this analysis.