Publications by authors named "Sergio Andrade"

Design: A review of the principal clinical applications of antimicrobial photodynamic therapy (aPDT) in dentistry.

Aim: To provide an overview of clinical applications and future perspectives of aPDT in dentistry.

Methods: A comprehensive search was conducted on PubMed, Web of Science, Scopus, and Embase up to September 2022, where only data from randomized clinical trials were included.

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Design: A review on antimicrobial resistance mechanisms discussing the main light-based antimicrobial approaches including ultraviolet light (UV), antimicrobial photodynamic therapy (aPDT), and antimicrobial blue light (aBL).

Aim: To describe antimicrobial resistance mechanisms and to present potential light-based alternatives to conventional antimicrobials.

Methods: The paper was divided into different topics, starting with an approach to antimicrobial resistance mechanisms.

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Background: Skin physiology seems to be influenced by dietary choices and body composition, although links between these factors remain poorly characterised. In the present manuscript, we elaborate on the potential relationships among food groups, body composition and skin physiology in omnivores and vegetarians.

Material And Methods: This cross-sectional observational study involved 181 participants, 129 omnivores and 52 vegetarians.

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Design: A critical review on the use of antimicrobials in dentistry.

Aim: To provide a general overview of the use of antimicrobials in dentistry.

Methods: The paper was divided into different topics, starting with an approach to understanding both commensal and pathogenic oral microbiota.

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Design: Prospective, parallel, randomized, double-blind, clinical trial.

Case Selection: Participants were at least 30 years old, who were systemically healthy, with stages III-IV, grades B-C periodontitis.

Data Analysis: Of the 50 eligible individuals for the study, 40 were divided into 2 equal groups.

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Data Sources: A comprehensive search was conducted on PubMed and Embase, adhering to the principles outlined in the PRISMA Extension for Scoping Reviews (PRISMA-ScR). The search strategy was subsequently registered on PROSPERO.

Study Selection: Articles were chosen based on an analysis of titles and abstracts, with no restrictions on publication date, language, or participant age.

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Erythromelalgia (EM) is a rare disease, which is still poorly characterized. In the present paper, we compared the hand perfusion of one female EM patient, under challenges, with a healthy control group. Using a laser Doppler flowmeter (LDF) with an integrated thermal probe, measurements were taken in both hands at rest (Phase I) and after two separate challenges-post-occlusive hyperemia (PORH) in one arm (A) and reduction of skin temperature (cooling) with ice in one hand (B) (Phase II).

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Data Sources: This study was conducted on a sample of patients who attended the dental clinic at Tufts University School of Dental Medicine, between January 1, 2019 and January 1, 2022. Ethical approval was obtained before commencing the research.

Study Selection: This cross-sectional study was carried out through an electronic search of electronic records.

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Data Sources: Electronic searches were conducted on databases (PubMed, EMBASE, and Google Scholar). In addition, websites of national organisations (US Food and Drug Administration, National Cancer Institute, Centres for Disease Control and Prevention, American Dental Association, Office of Disease Prevention and Health Promotion, National Institute on Drug Abuse, Agency for Healthcare Research and Quality) were also searched.

Study Selection: To achieve the objectives of the study, systematic reviews, controlled clinical trials, and observational studies published between October 2021 and February 2022 were considered.

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Data Sources: A search was conducted in PubMed and Cochrane Library databases for articles published in English between January 2012 and October 2022.

Study Selection: Articles were selected using both the term "electronic nicotine delivery system" (ENDS), as per the Medical Subject Heading (MeSH), in conjunction with specific oral domains. In vitro studies, animal models, unregistered clinical trials, and articles with conflicts of interest were excluded.

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Cardiovascular homeostasis involves the interaction of multiple players to ensure a permanent adaptation to each organ's needs. Our previous research suggested that changes in skin microcirculation-even if slight and distal-always evoke an immediate global rather than "local" response affecting hemodynamic homeostasis. These observations question our understanding of known reflexes used to explore vascular physiology, such as reactive hyperemia and the venoarteriolar reflex (VAR).

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Functional imaging with new photoacoustic tomography (PAT) offers improved spatial and temporal resolution quality in in vivo human skin vascular assessments. In the present study, we followed a suprasystolic reactive hyperemia (RH) maneuver with a multi-spectral optoacoustic tomography (MSOT) system. A convenience sample of ten participants, both sexes, mean age of 35.

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Background: Mobile applications (app) provide many benefits for healthcare professionals, making them a useful support clinical decision system.

Objectives: To describe the development of a mobile app, CalcVAN, to calculate vancomycin dosage regimens for adult and pediatric patients.

Methods: This study is a technological production research to develop a mobile app through the rapid prototyping type for the Android system in the Brazilian context.

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The COVID-19 pandemic imposed restrictive measures on dentistry in different regions of the world, ranging from stoppage of care to only permission for urgent and emergency dental services. Thus, new biosafety guidelines for resuming activities, whether in single dental offices, large clinics or dental education activities, are urgently required. In this sense, herein, guidelines that incorporate common points of the main protocols found in the literature for the resumption of dental activities at their different levels, whether in the scope of care or education, are presented.

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Introduction: Data on body composition, bone mineral density (BMD) and microarchitecture between cis and trans men are scarce. Few studies have reported trabecular bone score (TBS) data for transgender men using testosterone.

Experimental: We studied 19 transgender men and 19 cisgender men (mean age 23.

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Aim The aim of this randomised clinical trial based on cost-minimisation analysis was to assess and compare four post-retained restorative strategies for endodontically treated teeth.Methods A total of 225 endodontically treated teeth in 141 patients were evaluated annually between 2009 and 2018. In this sense, the teeth were divided into four groups according to the treatment strategy, where three groups were treated with glass fibre posts in combination with composite resin restorations or single metal-ceramic crown with or without ferrules, and one group was treated with cast metal posts with metal-ceramic crowns.

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Objective: To describe chickenpox outbreak among Venezuelan immigrants in shelters and occupancies in the municipalities of Pacaraima and Boa Vista, the state capital of Roraima, Brazil, and the control measures implemented.

Methods: This was a descriptive case series study, conducted between November 21 and December 13, 2019, based on secondary database obtained from the outbreak investigation made available by the General Coordination for the National Immunization Program. Descriptive analysis was performed using simple and relative frequency measurements, and measures of central tendency and dispersion were calculated.

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Peri-implant diseases, caused by bacteria from biofilm related to dental implants, are one of the main causes of late loss of implants. In this sense, peri-implant diseases are divided into peri-implant mucositis, when it affects only the soft tissues, and peri-implantitis, when there is a bone involvement, which can lead to the failure of dental implant therapy. Thus, biofilm removal is essential for peri-implant health, allowing long-term success in implant therapy.

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Muscle atrophy is a great consequence of spinal cord injuries (SCI) due to immobility. SCI's detrimental effects on large muscle groups may lead to secondary effects such as glucose intolerance, increased risk of metabolic syndrome, and diabetes. Exercising with blood flow restriction (BFR) has been proposed as an effective method to induce hypertrophy using low training loads, with little or no muscle damage.

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Risk assessment is considered an essential tool to assist in the management and mitigation of polluted areas, especially those associated with economic activities that significantly degrade the environment, such as mining. However, most of the methodologies of risk assessment adopt the deterministic approach of using a fixed value for ascertaining the hazards derived from exposure to chemical pollutants. However, this is not the case of the Human, Ecological and Radiological Risk (HERisk) code, which allows space-time assessments of ecological, radiological, and human health risks.

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Benth oleoresin (CPO) is used as an anti-inflammatory, wound healing, and antimicrobial. This paper reports the cytotoxic, anti-inflammatory, and antinociceptive activities of CPO. CPO (10 mg/kg) did not affect locomotor capacity in the open-field and rotarod tests and was not cytotoxic to CHO-k1, THP-1, and L929 cell lines.

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Ethnopharmacological Relevance: Propolis has been used in folk medicine to treat gastric disorders for centuries. However, although studies have been conducted to validate the gastroprotective and anti-ulcer activity of some types of propolis, red propolis activity remains unknown.

Aim Of The Study: The present study aimed to evaluate the gastroprotective effect of the hydroalcoholic extract of red propolis (HERP), its mode of action, and the main compounds involved in its activity, therefore contributing to validate the chemical and pharmacological potential of this product.

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Mart. (Amaranthaceae) is used in folk medicine as a natural analgesic, and in Brazil, the species of genus is used for rheumatism. However, scientific evidence which supports its popular use as an analgesic is scarce.

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Article Synopsis
  • Jatropha elliptica roots are traditionally used to treat gastric ulcers, and this study investigates the gastroprotective effects and toxicity of its ethanol extract and hexane fraction in mice.
  • The findings show that both the extracts significantly reduced gastric lesions in ulcer models without causing any acute toxicity symptoms.
  • Key compounds identified include fraxetin and jatrophone, with cyperenoic acid showing notable potency in reducing gastric lesions and preserving the gastric mucus layer, indicating its potential as a protective agent.
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The p-coumaric acid is a phenolic compound present in large quantities in the extract of Baccharis dracunculifolia DC, a Brazilian medicinal plant used to treat gastric ulcer. Given the necessity for finding new chemical components capable of accelerating gastric healing, in this study, the effects of the p-coumaric acid were evaluated in the acetic acid-induced ulcer model in rats, where histological, inflammatory, and oxidative parameters were analyzed. The healing property was also evaluated in the scratch assay on fibroblast cells (L929) and the cytotoxicity of p-coumaric acid was assessed in both L929 and human gastric adenocarcinoma (AGS) cells by MTT assay.

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