[Advances in surgical endoscopy: initial experience in endoscopic colonic submucosal dissection (ESD) in Costa Rica].

Objectives: To report the first case in Costa Rica of a colon tumor removed by endoscopic submucosal dissection (ESD).

Patient And Method: We describe the case of a 70-year-old man with a multilobulated 25 millimeters tumor located in the cecum, near the ileocecal valve, detected during a routine colonoscopic check-up. The biopsy revealed a tubular adenoma with high grade dysplasia and the patient underwent an endoscopic submucosal en-bloc dissection of the lesion.

[Follow-up after curative surgery for colorectal cancer: impact of positron emission tomography - computed tomography (PET/CT)].

Unlabelled: Postoperative surveillance has an important role in patient survival after curative resection of colorectal cancer.

Objectives: To describe the characteristics of the follow-up with positron emission tomography (PET) / computed tomography (CT)(PET/CT) and its impact in colorectal cancer (CRC) survivors after curative resection in a university hospital in Tochigi Prefecture, Japan.

Materials And Methods: Consecutive review of patient's hospital charts who underwent presurgical staging with PET/CT for curative resection of colorectal cancer between April 2005 and March 2008.

The mechanical binding strengths of Helicobacter pylori BabA and SabA adhesins using an adhesion binding assay-ELISA, and its clinical relevance in Japan.

To elucidate a potential role for H. pylori BabA and SabA adhesins in the pathogenesis of gastric mucosal lesions, the MBS of BabA and SabA was examined using an in-house ABA-ELISA. Ninety isolates from Japanese patients with gastric cancer (n= 43) and non-cancerous (n= 47) lesions were subjected to an ABA-ELISA which had been developed in-house, and sequential analysis of the babA2 middle region.

Clinical relevance of Helicobacter pylori babA2 and babA2/B in Costa Rica and Japan.

Aim: To evaluate the prevalence of Helicobacter pylori (H. pylori) babA2, babB and a recombinant gene between babA2 and babB (babA2/B), and their role in the development of atrophic gastritis in Costa Rican and Japanese clinical isolates.

Methods: A total of 95 continuous H.

[Transvaginal notes Cholecystectomy in humans: first series of cases in Costa Rica].

OBJECTIVES. To report the first case series of transvaginal NOTES cholecystectomy in humans in Costa Rica and its clinical potential in the treatment of abdominal diseases in this country. PATIENTS AND METHODS.

[Endoscopic submucosal dissection (esd) for the curative treatment of early gastric cancer: initial experience in Costa Rica].

OBJECTIVES. To report the first case of endoscopic submucosal dissection (ESD) in Costa Rica and to analyze the future impact of this technique for the treatment of early gastric cancer in this country. PATIENTS AND METHODS.

Application of endoscopic submucosal dissection for removal of deep invasive submucosal colon carcinoma.

Endoscopic submucosal (sm) dissection (ESD) is a recently used technique that enables en-bloc resection of large colorectal tumors allowing a more precise histopathological analysis of the resected specimen. However, it has not been widely adopted even in Japan mainly due to its technical difficulty and increased risk of perforation. Herein, we present an ESD-treated lesion with deep sm invasion removed without complications, such as bleeding or perforation, from a patient at high-risk for surgical intervention.

Challenges and lessons learned from NOTES cholecystectomy initial experience: a stepwise approach from the laboratory to clinical application.

Background/purpose: The initial idea behind natural orifice transluminal endoscopic surgery (NOTES) was that of an incisionless surgery. NOTES cholecystectomy is a good model of human ingenuity and technological advance. NOTES cholecystectomy in a human being was performed at our institution after extensive laboratory work in live pig models.

Role of bacterial and genetic factors in gastric cancer in Costa Rica.

Aim: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR).

Methods: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1beta and IL-10 by PCR-RFLP, and IL-1RN by PCR.

Serum pepsinogen levels, Helicobacter pylori CagA Status, and cytokine gene polymorphisms associated with gastric premalignant lesions in Costa Rica.

The detection of gastric premalignant lesions, atrophic gastritis, corpus atrophic gastritis, and intestinal metaplasia, using several potential markers was examined in Costa Rica. Depending on the lesion investigated, from a total of 223 dyspeptic patients, 58 (26.0%), 31 (13.

Diversity of Helicobacter pylori cagA and vacA genes in Costa Rica: its relationship with atrophic gastritis and gastric cancer.

Background: Associations between Helicobacter pylori gene diversity and gastric cancer have not been reported on in Costa Rica, despite its being one of the countries with the highest gastric cancer incidence and mortality rates in the world. The aim of this study was to determine the prevalence of H. pylori cagA and vacA genes and investigate whether it could be correlated with atrophic gastritis (AG) and gastric cancer (GC) in Costa Rica.

Helicobacter pylori CagA status associated with gastric cancer incidence rate variability in Costa Rican regions.

Background: We evaluated several risk factors for gastric cancer in Costa Rican regions having contrasting gastric cancer incidence rates, despite the small dimensions of the country.

Methods: A total of 180 dyspeptic patients were classified into two groups according to the gastric cancer incidence (GCI) rate in their Costa Rican region: group A, with a high GCI rate (n = 91) and group B, with a low GCI rate (n = 89). Helicobacter pylori infection was detected by rapid urease test, Gram staining, and histological observation.

Cell elongation and cell death of helicobacter pylori is modulated by the disruption of cdrA (cell division-related gene A).

The cell division-related gene A (cdrA) of Helicobacter pylori is dispensable in vivo and unique in having a repressive role on cell division and long-term survival. To clarify its role, comparisons of the wildtype HPK5 and isogenic cdrA-disrupted mutant HPKT510 were examined by ultrastructural morphology, PBP profiles, and susceptibility to beta-lactam antibiotics during long-term cultivation. Ultrastructural analyses revealed that the shorter rods of HPKT510 had a slightly wider periplasmic space between the inner and the outer membrane than those of HPK5.