Silent Death by Sound: C Fullerene Sonodynamic Treatment of Cancer Cells.

The acoustic pressure waves of ultrasound (US) not only penetrate biological tissues deeper than light, but they also generate light emission, termed sonoluminescence. This promoted the idea of its use as an alternative energy source for photosensitizer excitation. Pristine C fullerene (C), an excellent photosensitizer, was explored in the frame of cancer sonodynamic therapy (SDT).

Drug delivery with a pH-sensitive star-like dextran-graft polyacrylamide copolymer.

The development of precision cancer medicine relies on novel formulation strategies for targeted drug delivery to increase the therapeutic outcome. Biocompatible polymer nanoparticles, namely dextran--polyacrylamide (D--PAA) copolymers, represent one of the innovative non-invasive approaches for drug delivery applications in cancer therapy. In this study, the star-like D--PAA copolymer in anionic form (D--PAAan) was developed for pH-triggered targeted drug delivery of the common chemotherapeutic drugs - doxorubicin (Dox) and cisplatin (Cis).

Pepper Bacterial Spot Control by : Bioprocess Solution.

Pepper bacterial spot is one of the most severe plant diseases in terms of infection persistence and economic losses when it comes to fresh pepper fruits used in nutrition and industrial processing. In this study, IP22 isolated from fresh cheese was used as a biocontrol agent of pepper bacterial spot, whose main causal agent is the cosmopolitan pathogen . After optimization of the cultivation medium composition aimed at maximizing of the antimicrobial activity against and validation of the optimized medium at the scale of a laboratory bioreactor, in planta tests were performed.

C Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells.

A herbal alkaloid Berberine (Ber), used for centuries in Ayurvedic, Chinese, Middle-Eastern, and native American folk medicines, is nowadays proved to function as a safe anticancer agent. Yet, its poor water solubility, stability, and bioavailability hinder clinical application. In this study, we have explored a nanosized carbon nanoparticle-C fullerene (C)-for optimized Ber delivery into leukemic cells.

Synergy of Chemo- and Photodynamic Therapies with C Fullerene-Doxorubicin Nanocomplex.

A nanosized drug complex was explored to improve the efficiency of cancer chemotherapy, complementing it with nanodelivery and photodynamic therapy. For this, nanomolar amounts of a non-covalent nanocomplex of Doxorubicin (Dox) with carbon nanoparticle C fullerene (C) were applied in 1:1 and 2:1 molar ratio, exploiting C both as a drug-carrier and as a photosensitizer. The fluorescence microscopy analysis of human leukemic CCRF-CEM cells, in vitro cancer model, treated with nanocomplexes showed Dox's nuclear and C's extranuclear localization.

Correction to: Complexation with C Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro.

Following publication of the original article [1], the authors flagged that there was unfortunately an error with Fig. 3 of the article.

Complexation with C Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro.

Conventional anticancer chemotherapy is limited because of severe side effects as well as a quickly evolving multidrug resistance of the tumor cells. To address this problem, we have explored a C fullerene-based nanosized system as a carrier for anticancer drugs for an optimized drug delivery to leukemic cells.Here, we studied the physicochemical properties and anticancer activity of C fullerene noncovalent complexes with the commonly used anticancer drug doxorubicin.

HPLC-ESI-MS method for C fullerene mitochondrial content quantification.

The presented dataset describes the quantification of carbon nanoparticle C fullerene accumulated in mitochondria of human leukemic cells treated with nanostructure. Firstly, the high performance liquid chromatography-electro spray ionization-mass spectrometry (HPLC-ESI-MS) method was developed for quantitative analysis of pristine C fullerene. Then, human leukemic cells were incubated with C fullerene, homogenized and subjected to the differential centrifugation to retrieve mitochondrial fraction.

C fullerene accumulation in human leukemic cells and perspectives of LED-mediated photodynamic therapy.

Recent progress in nanobiotechnology has attracted interest to a biomedical application of the carbon nanostructure C fullerene since it possesses a unique structure and versatile biological activity. C fullerene potential application in the frame of cancer photodynamic therapy (PDT) relies on rapid development of new light sources as well as on better understanding of the fullerene interaction with cells. The aim of this study was to analyze C fullerene effects on human leukemic cells (CCRF-CEM) in combination with high power single chip light-emitting diodes (LEDs) light irradiation of different wavelengths: ultraviolet (UV, 365 nm), violet (405 nm), green (515 nm) and red (632 nm).