Publications by authors named "Sergi Tosal-Castano"
Membrane contact sites facilitate the exchange of metabolites between organelles to support interorganellar communication. The nucleus-vacuole junctions (NVJs) establish physical contact between the perinuclear endoplasmic reticulum (ER) and the vacuole. Although the NVJ tethers are known, how NVJ abundance and composition are controlled in response to metabolic cues remains elusive.
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- The mitochondrial proteome relies heavily on importing proteins encoded by nuclear DNA, which usually have cleavable presequences for targeting.
- Impaired processing of these presequences leads to an accumulation of unprocessed proteins in mitochondria that form aggregates but do not immediately result in cell death.
- Instead, cells activate an early mitochondrial unfolded protein response (mtUPR)-like mechanism, involving the recruitment of the transcription factor Rox1, to help maintain mitochondrial function and manage the stress effectively.
Mitochondrial dysfunction is a prominent trait of cellular decline during aging and intimately linked to neuronal degeneration during Parkinson's disease (PD). Various proteins associated with PD have been shown to differentially impact mitochondrial dynamics, quality control and function, including the leucine-rich repeat kinase 2 (LRRK2). Here, we demonstrate that high levels of the enzymatic core of human LRRK2, harboring GTPase as well as kinase activity, decreases mitochondrial mass via an impairment of mitochondrial biogenesis in aging yeast.
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