Impact of metallic coating on the retention of Ac and its daugthers within core-shell nanocarriers.

Currently, alpha-emitting radionuclide Ac is one of the most promising isotopes in alpha therapy due to its high linear energy transfer during four sequential alpha decays. However, the main obstacle preventing the full introduction of Ac into clinical practice is the lack of stable retention of radionuclides, leading to free circulation of toxic isotopes in the body. In this work, the surface of silica nanoparticles (SiO NPs) has been modified with metallic shells composed of titanium dioxide (TiO) and gold (Au) nanostructures to improve the retention of Ac and its decay products within the developed nanocarriers.

Application of Sr/ Rb generator in neurooncology.

Introduction: The applicability of "Rubidium Chloride, Rb from Generator" radiopharmaceutical for brain tumors (BT) diagnostics is demonstrated on the basis of the application experience of the radiopharmaceutical in neurooncology.

Experimental: A total of 21 patients with various brain tumors and nonneoplastic abnormal brain masses were investigated.

Results And Discussions: The results of the imaging and differential diagnostics of malignant and benign tumors, nonneoplastic abnormal brain masses and lesions revealed the prevalence of high uptake of the radiopharmaceutical in the malignant tumors in comparison with benign glioma and arteriovenous malformations in which Rb-chloride accumulates in the vascular phase but does not linger further.